| Title | Adsorptive stripping measurements of iron accumulation in mice kidney using microelectrodes and histological features |
| Publication Type | Journal Article |
| 1998 |
| Authors | Pereira, MC, Pereira, ML, Sousa, JP |
| Journal | Journal of Trace Elements in Medicine and BiologyJ. Trace Elem. Med. Biol. |
| Volume | 12 |
| Issue | 1 |
| Pagination | 50 - 55 |
| Date Published | 1998/// |
| 0946672X (ISSN) |
| , biomaterials, Adsorptive stripping, animal experiment, animal model, animal tissue, Animals, article, atomic absorption spectrometry, biomaterial, controlled study, electrochemical analysis, electrochemistry, histology, Iron, iron absorption, Kidney, male, Mercury, metal implantation, Mice, microelectrode, Microelectrodes, mouse, nonhuman, potentiometry, priority journal, Toxicology |
| The toxic effects caused by iron in kidney was performed on experimental studies with mice following administration of a metallic solution of this specie to simulate the iron corrosion products of a metallic implant. To quantify the total levels of iron present in this organ, an electrochemical method was chosen based on the application of square wave voltammetry using adsorptive collection of iron-catechol on a mercury film microelectrode (MFM). The optimal working conditions to produce a very stable and reproducible iron peak in the digested kidney samples were found to be pH=7.2 provided by 8.0 mmol/L PIPES buffer, catechol concentration of 3.0x10 |
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