| Title | Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels |
| Publication Type | Journal Article |
| 2005 |
| Authors | Ferreira, L, Gil, MH, Cabrita, AMS, Dordick, JS |
| Journal | BiomaterialsBiomaterials |
| Volume | 26 |
| Issue | 23 |
| Pagination | 4707 - 4716 |
| Date Published | 2005/// |
| 01429612 (ISSN) |
| Absorbable Implants, adipic acid derivative, animal experiment, animal tissue, Animals, article, Bacillus subtilis, Biocatalysts, Biocompatibility, Biocompatible Materials, Biodegradation, Biomedical engineering, biosynthesis, catalysis, Controlled drug delivery, controlled study, Cross-linking, dextran, Dextran-based hydrogels, Dextrans, dimethyl sulfoxide, Dimethylsulfoxide, Elastic moduli, Elasticity, Enzyme, Foreign-Body Reaction, hydrogel, Hydrogels, implantation, in vivo study, Inflammation, male, materials testing, nonhuman, Peptide Hydrolases, porosity, priority journal, rat, Rats, Rats, Wistar, substitution reaction, Sulfur compounds, Surface Properties, Swelling, Swelling ratio, synthesis, Tissue, transesterification, Transesterification reactions |
| We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 μm depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery. © 2004 Elsevier Ltd. All rights reserved. |
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