| Title | Biodegradable chitosan-silicate porous hybrids for drug delivery |
| Publication Type | Book |
| Year of Publication | 2008 |
| Authors | Shirosaki, Y, Tsuru, K, Hayakawa, S, Osaka, A |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 361-363 II |
| Number of Pages | 1219 - 1222 |
| ISBN Number | 10139826 (ISSN) |
| Keywords | biodegradability, Buffer saline solution, chitosan, Chitosan silicate hybrid, Chitosan-silicate hybrid, Drug delivery, Porous materials, Proteins, Silicates, Synthesis (chemical) |
| Abstract | Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-38149045782&partnerID=40&md5=520d7fffb6d19fcc96b3fa38036f9bf6 |
