| Title | Biological Activity of Two Glass Ceramics in the Meta- and Pyrophosphate Region: A Comparative Study |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Dias, AG, Costa, MA, Lopes, MA, Santos, JD, Fernandas, MH |
| Series Editor | M.A., B, F.J., M, R., C, B., L |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 254-256 |
| Number of Pages | 825 - 828 |
| City | Porto |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Adhesion, Biodegradable glass ceramics, Biodegradation, Bone, cell proliferation, Cells, Crystallization, Degradation, Glass ceramics, incubation time, MG63 osteoblast-like cells, Scanning electron microscopy, X ray diffraction |
| Abstract | Based upon the CaO-P 2O
5 glass system, two glass ceramics were prepared in the metaand pyrophosphate regions. The present work describes preliminary results concerning the biological activity of MK5B (45CaO-45P
2O
5-5MgO-5K20, in mol %) and MT13B (45CaO-37P
2O
55-5MgO-13TiO
2, in mol %) using MG63 osteoblast-like cells. Both materials supported cell growth and proliferation which increased with the incubation time. However, cell growth was significantly lower on seeded MK5B samples. SEM observation showed that cell adhesion and spreading were hampered on this material. Evident degradation of the material surface was observed with simultaneous cell proliferation and material precipitation. By contrast, MT13B presented a relatively stable surface throughout the culture time. Results suggest that the in vitro biological behaviour of MK5B and MT13B is related with differences in the degradation rates of the two materials during the culture time.
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| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0348146001&partnerID=40&md5=5245524d4dfb5615946aadcf5eb7c37a |
