| Title | Biological behaviour of Bonelike® graft implanted in the tibia of humans |
| Publication Type | Book |
| Year of Publication | 2005 |
| Authors | Gutierres, M, Hussain, NS, Afonso, A, Almeida, L, Cabral, T, Lopes, MA, Santos, JD |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 284-286 |
| Number of Pages | 1041 - 1044 |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Biological behavior, Bone, Bonelike® graft, Clinical trials, histology, hydroxyapatite, Implants (surgical), Radiology, Scanning electron microscopy, Surgery, Synthetic grafting material |
| Abstract | This paper reports the ability of Bonelike® to regenerate bone defected areas when implanted in the tibia of 3 patients (average age of 59 years) during a high tibial osteotomy (HTO) to treat medial compartment osteoarthritis of the knee. Bonelike® is a synthetic bone graft designed to mimic the inorganic composition of bone using a patent process that consists of liquid sintering hydroxyapatite in the presence of CaO-P 2O
5 based glass. The preliminary clinical evaluation performed showed that an intimate contact between new formed bone and Bonelike® was established (67±10%), with no fibrous interface. Therefore, Bonelike® is a single-handedly viable osteoconductive synthetic grafting material as it has been demonstrated from the profiles of radiological, histological and scanning electron microscopy analyses for the six months implantation period.
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| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-33744540330&partnerID=40&md5=c7f109dc068a35ed53047b8426a85a1d |
