| Title | Bonelike®/PLGA hybrid materials for bone regeneration: In vivo evaluation |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Oliveira, JM, Kawai, T, Lopes, MA, Ohtsuki, C, Santos, JD, Afonso, A |
| Series Editor | R., M, E., F, I., F, C., D |
| Series Title | Materials Science ForumMater Sci Forum |
| Volume | 455-456 |
| Number of Pages | 374 - 377 |
| City | Caparica |
| ISBN Number | 02555476 (ISSN) |
| Keywords | Bacteria, Biodegradation, Bone, Bonelike resorption, Bonelike®, Histological studies, histology, Hybrid materials, hydroxyapatite, In vivo, physiology, PLGA, Polymers, Surgery, Tissue |
| Abstract | The biocompatibility and osteoconductive potential of Bonelike® and Bonelike®/PLGA hybrid materials were evaluated through subcutaneous and tibiae implantations for a 4 week period. Qualitative histology was performed to evaluate new bone formation and characterise bone-implant interface and results showed that Bonelike®/PLGA hybrid materials promote extensive bone growth. After the 4 week implantation period, Bonelike® resorption was recognized, which may be due to the presence of resorbable β and α-tricalcium phosphate phases. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-17044449739&partnerID=40&md5=4d9e5103b703ff0f016854e278f75823 |
