| Title | Cancer syndromes and therapy by stop-codon readthrough |
| Publication Type | Journal Article |
| 2012 |
| Authors | Bordeira-Carriço, R, Pêgo, AP, Santos, M, Oliveira, C |
| Journal | Trends in Molecular MedicineTrends Mol. Med. |
| Volume | 18 |
| Issue | 11 |
| Pagination | 667 - 678 |
| Date Published | 2012/// |
| 14714914 (ISSN) |
| Aminoglycosides, Hereditary cancer syndromes, Nonsense-mediated decay (NMD), Nonsense-suppression, Premature termination codon (PTC), PTC124, Readthrough, Suppressor-tRNA |
| Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting translation termination factors are, among others, potential strategies for treating PTC-associated diseases. In this review, the potential of using readthrough strategies as a therapy for cancer syndromes is discussed, and we consider the effect of nonsense-mediated decay and other factors on readthrough efficiency. © 2012 Elsevier Ltd. |
| http://www.scopus.com/inward/record.url?eid=2-s2.0-84868212770&partnerID=40&md5=93ff561cb7d1c818f78a88ec1555181e |
