| Title | Cell-induced response by tetracyclines on human bone marrow colonized hydroxyapatite and Bonelike ®
|
| Publication Type | Journal Article |
| 2008 |
| Authors | Gomes, PS, Santos, JD, Fernandes, MH |
| Journal | Acta BiomaterialiaActa Biomater. |
| Volume | 4 |
| Issue | 3 |
| Pagination | 630 - 637 |
| Date Published | 2008/// |
| 17427061 (ISSN) |
| adult, alkaline phosphatase, alkaline phosphatase bone isoenzyme, antimicrobial activity, article, Bacteria (microorganisms), bone infection, bone marrow cell, Bone Marrow Cells, Bone Substitutes, Bonelike, Calcium, calcium phosphate, Cell culture, cell function, cell proliferation, cell survival, cell viability, Cells, Cultured, concentration response, controlled study, Culture Media, culture medium, doxycycline, Durapatite, enzyme activity, extracellular matrix, glass, human, human cell, Humans, hydroxyapatite, implant, Microscopy, Electron, Scanning, Middle Aged, Minerals, minocycline, osteoblast, Osteoblasts, priority journal, Scanning electron microscopy, stroma cell, Tetracycline, tetracycline derivative, Tetracyclines, X-Ray Diffraction |
| Semi-synthetic tetracyclines are commonly used antibiotics that also seem to play an important role in the modulation of the immuno-inflammatory imbalance, verified in several bone diseases. The association of a therapeutic agent (that prevents bacterial infection and induces tissue formation) to a biomaterial aiming to repair/regenerate bone defects could contribute to a more predictable clinical outcome. The present study intends to evaluate the proliferation and functional activity of osteoblast-induced human bone marrow cells, cultured on the surface of hydroxyapatite (HA) and Bonelike ®, in the presence of therapeutic concentrations of doxycycline and minocycline. First passage bone marrow cells were cultured for 35 days on the surface of HA and Bonelike
® discs, in the absence or presence of 1 μg ml
|
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