| Title | Effect of calcium phosphate addition to alginate microspheres: modulation of enzyme release kinetics and improvement of cell adhesion |
| Publication Type | Book |
| Year of Publication | 2005 |
| Authors | Barrias, CC, Ribeiro, CC, Rodrigues, D, Miranda, MCS, Barbosa, MA |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 284-286 |
| Number of Pages | 689 - 692 |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Alginate, Bioceramics, calcium phosphate, Calcium titanium phosphate, cell adhesion, Enzyme kinetics, Enzyme release, hydroxyapatite, Microspheres, Osteoblasts |
| Abstract | In this study, the addition of calcium phosphate powders to an alginate matrix was evaluated as a strategy to modulate enzyme release-kinetics from alginate microspheres and, simultaneously, to improve cell adhesion to the polymer. Pre-adsorption of the enzyme to the ceramic powders resulted in a more adequate release pattern. The ratio of ceramic-to-polymer had a pronounced effect on osteoblast adhesion to microspheres. Cells were only able to spread on microspheres with the highest percentage of ceramic (0.4 w/w using a 1.5% w/v alginate solution). |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-20744433251&partnerID=40&md5=30ce8fc67d1e3e37074cc056f650b798 |
