| Title | Epithelial E- and P-cadherins: Role and clinical significance in cancer |
| Publication Type | Journal Article |
| 2012 |
| Authors | Paredes, J, Figueiredo, J, Albergaria, A, Oliveira, P, Carvalho, J, Ribeiro, AS, Caldeira, J, Costa, AM, Simões-Correia, J, Oliveira, MJ, Pinheiro, H, Pinho, SS, Mateus, R, Reis, CA, Leite, M, Fernandes, MS, Schmitt, F, Carneiro, F, Figueiredo, C, Oliveira, C, Seruca, R |
| Journal | Biochimica et Biophysica Acta - Reviews on CancerBiochim. Biophys. Acta Rev. Cancer |
| Volume | 1826 |
| Issue | 2 |
| Pagination | 297 - 311 |
| Date Published | 2012/// |
| 0304419X (ISSN) |
| antineoplastic activity, antineoplastic agent, Breast, breast cancer, Cancer, cancer chemotherapy, cancer model, cancer survival, drug effect, E-cadherin, Gastric, gene expression regulation, gene function, gene location, gene overexpression, gene structure, genetic association, genetic code, Helicobacter infection, Hereditary diffuse gastric cancer, human, in vivo study, loss of function mutation, lymph node metastasis, malignant neoplastic disease, molecular dynamics, molecular pathology, molecularly targeted therapy, nonhuman, P cadherin, P cadherin gene, P-cadherin, pf 03732010, priority journal, protein expression, protein function, protein inhibitor, protein processing, review, signal transduction, stomach cancer, transcription regulation, tumor gene, unclassified drug, uvomorulin, uvomorulin gene, vasculotropin inhibitor |
| E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models. © 2012 Elsevier B.V. |
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