



@article {2189,
	title = {E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions},
	journal = {FEBS LettersFEBS Lett.},
	volume = {586},
	year = {2012},
	note = {Export Date: 21 November 2012Source: ScopusCODEN: FEBLAdoi: 10.1016/j.febslet.2012.07.045PubMed ID: 22841718Language of Original Document: EnglishCorrespondence Address: Seruca, R.; IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal; email: rseruca@ipatimup.ptChemicals/CAS: uvomorulin, 112956-45-3; CadherinsReferences: Milne, A.N., Carneiro, F., O{\textquoteright}Morain, C., Offerhaus, G.J., Nature meets nurture: Molecular genetics of gastric cancer (2009) Hum. Genet., 126, pp. 615-628. , 10.1007/s00439-009-0722-x;Lauren, P., The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification (1965) Acta. Pathol. Microbiol. Scand., 64, pp. 31-49; 
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},
	month = {2012///},
	pages = {2981 - 2989},
	abstract = {E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families. {\textcopyright} 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.},
	keywords = {Adhesion, Cadherins, cancer growth, cancer invasion, cancer patient, cancer susceptibility, cell adhesion, complex formation, conference paper, E-cadherin, embryo development, endocytosis, epigenetics, epithelial mesenchymal transition, Gastric cancer, gene mutation, gene silencing, genetic susceptibility, Germ-Line Mutation, HDGC, Helicobacter infection, Helicobacter Infections, Helicobacter pylori, histone deacetylase inhibitor, human, Humans, Invasion, metastasis, molecular pathology, nonhuman, priority journal, protein analysis, protein depletion, protein expression, protein function, protein structure, regulatory mechanism, signal transduction, Signalling, stomach cancer, stomach carcinogenesis, Stomach Neoplasms, Tumour, uvomorulin},
	isbn = {00145793 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922992\&partnerID=40\&md5=455ae054dc6c8f95dc9e81d77fec1ad9},
	author = {Carneiro, P. and Fernandes, M.S. and Figueiredo, J. and Caldeira, J. and Carvalho, J. and Pinheiro, H. and Leite, M. and Melo, S. and Oliveira, P. and Sim{\~o}es-Correia, J. and Oliveira, M.J. and Carneiro, F. and Figueiredo, C. and Paredes, J. and Oliveira, C. and Seruca, R.}
}
