



@article {2357,
	title = {Bone ingrowth in macroporous Bonelike                    {\textregistered} for orthopaedic applications
},
	journal = {Acta BiomaterialiaActa Biomater.},
	volume = {4},
	year = {2008},
	note = {Cited By (since 1996): 13Export Date: 21 November 2012Source: Scopusdoi: 10.1016/j.actbio.2007.06.009PubMed ID: 17716960Language of Original Document: EnglishCorrespondence Address: Santos, J.D.; FEUP - Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; email: jdsantos@fe.up.ptChemicals/CAS: Bone SubstitutesTradenames: BonelikeReferences: Akamatsu, Y., Koshino, T., Saito, T., Wada, J., Changes in osteosclerosis of the osteoarthritic knee after high tibial osteotomy (1997) Clin Orthop, 334, pp. 207-214;Coventry, M.B., Ilstrup, D.M., Wallrichs, S.L., Proximal tibial osteotomy. A critical long-term study of eighty-seven cases (1993) J Bone Joint Surg, 75 -A, pp. 196-201; 
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},
	month = {2008///},
	pages = {370 - 377},
	abstract = {The aim of this study was to evaluate the biological behaviour of porous scaffold structures of Bonelike                        {\textregistered} which is suitable for either direct clinical use or tissue engineering applications. Porous cylindrical specimens 8 {\texttimes} 10 mm were implanted in the lateral aspect of the tibia of 13 patients (mean age 54 years), during osteotomy surgery for the treatment of medial compartment osteoarthritis of the knee. Implanted cylinders were retrieved at the same time as the removal of the blade plates at 3, 6, 9 and 12 months. Scanning electron microscopy and histological evaluations were performed to observe the biological responses of human bone tissue to porous Bonelike
                        {\textregistered}. The penetration depth was determined for all implantation periods, and after 6 months it was already possible to see new bone in the centre of the implanted cylinders, which gives 100\% of penetration depth for all implantations periods except for 3 months when bone could only be seen in the peripherical region. Regarding the percentage of the area covered by new bone calculated from two-dimensional histological sections, values of 53 {\textpm} 15, 76 {\textpm} 12 and 88 {\textpm} 9\% were achieved for 6, 9 and 12 months, respectively. Due to its structural features porous Bonelike
                        {\textregistered} permitted effective vascularization and bone ingrowth, and therefore was fully osteointegrated as shown in the histological surveys. A slow biomaterial degradation with implantation time is envisaged since the material has displayed surface degradation. Bonelike
                        {\textregistered} scaffolds show potential for complete ingrowth of osseous tissue and restoration of vascularization throughout the defected site. {\textcopyright} 2007.
},
	keywords = {adult, aged, article, biomaterial, bone defect, Bone graft, bone growth, Bone Regeneration, Bone Substitutes, bone tissue, Bonelike, clinical article, controlled study, Female, histology, human, human tissue, Humans, implant, knee osteoarthritis, male, materials testing, Microscopy, Electron, Scanning, Middle Aged, molecular scaffold, Orthopaedic, orthopedics, Osseointegration, Osteoarthritis, osteotomy, porosity, Porous materials, priority journal, Prostheses and Implants, Scanning electron microscopy, tibia, Time Factors, Tissue engineering, tissue section, vascularization, {\textregistered}},
	isbn = {17427061 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-38949142954\&partnerID=40\&md5=ab5a278b6d421b9e8e96f9397b7c54e1},
	author = {Gutierres, M. and Lopes, M.A. and Sooraj Hussain, N. and Lemos, A.F. and Ferreira, J.M.F. and Afonso, A. and Cabral, A.T. and Almeida, L. and Santos, J.D.}
}
