



@article {2382,
	title = {Physicochemical degradation studies of calcium phosphate glass ceramic in the CaO-P                    2O
                    5-MgO-TiO
                    2 system
},
	journal = {Acta BiomaterialiaActa Biomater.},
	volume = {3},
	year = {2007},
	note = {Cited By (since 1996): 5Export Date: 21 November 2012Source: Scopusdoi: 10.1016/j.actbio.2006.09.009PubMed ID: 17150421Language of Original Document: EnglishCorrespondence Address: Lopes, M.A.; Instituto de Engenharia Biom{\'e}dica (INEB), Laborat{\'o}rio de Biomateriais, Rua do Campo Alegre 823, 4150-180 Porto, Portugal; email: malopes@fe.up.ptChemicals/CAS: calcium ion, 14127-61-8; hydroxyapatite, 1306-06-5, 51198-94-8; phosphate, 14066-19-4, 14265-44-2; titanium, 7440-32-6; Biocompatible Materials; Calcium Compounds; calcium phosphate, 10103-46-5; Calcium Phosphates; Ceramics; Glass ceramics, 85422-94-2; lime, 1305-78-8; Magnesium Oxide, 1309-48-4; Oxides; Phosphorus Compounds; phosphorus pentoxide, 1314-56-3; titanium dioxide, 13463-67-7; Titanium, 7440-32-6References: (2003) Bone graft substitutes, , Laurencin C.T. (Ed), ASTM International;(1993) Introduction to bioceramics, , Hench L.L., and Wilson J. (Eds), World Scientific, Singapore; 
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},
	month = {2007///},
	pages = {263 - 269},
	abstract = {The aim of this work was to evaluate the in vitro degradation behaviour of a 45CaO-37P                        2O
                        5-5MgO-13TiO
                        2 (mol.\%) glass ceramic, under two different simulated physiological conditions: normal physiological pH 7.4, and pH 3.0, which was designed to simulate the acidic conditions produced by osteoclast cells. The in vitro testing was carried out at 37 {\textdegree}C for up to 42 days for the pH 7.4 solution and for up to 1 day for the pH 3.0 solution. The incorporation of TiO
                        2 into the glass structure leads to the precipitation of specific crystalline phases in the glass matrix, namely α- and β-Ca
                        2P
                        2O
                        7, TiP
                        2O
                        7 and CaTi
                        4(PO
                        4)
                        6. The degradation testing at pH 3.0 showed a higher weight loss compared with degradation testing at pH 7.4; the weight loss under the acidic condition after 1 day (24 h) was about 10 times higher than the weight loss after 42 days of immersion at pH 7.4. The ionic release profile of Ca
                        2+, PO
                        4
                        3 -, Mg
                        2+ and Ti
                        4+ showed a continuous increase in concentration over all immersion times for both testing solutions. After 1 day of immersion at pH 3.0, the concentration levels of Mg
                        2+, Ca
                        2+, PO
                        4
                        3 - were about six times higher than the levels achieved after 42 days of immersion at pH 7.4. The glass ceramic showed similar degradation to hydroxyapatite, and therefore has potential to be used in certain clinical applications where relatively slow resorption of the implant and replacement by bone is required, e.g. cranioplasty. {\textcopyright} 2006 Acta Materialia Inc.
},
	keywords = {acidity, article, Biocompatible Materials, Biomaterials, Bone, Bone and Bones, bone prosthesis, Calcium Compounds, calcium ion, calcium phosphate ceramic, Calcium phosphates, ceramics, Chemical structure, concentration response, controlled study, cranioplasty, Crystallization, Degradation, glass, Hydrogen-Ion Concentration, hydroxyapatite, In vitro biodegradation, in vitro study, Magnesium Oxide, materials testing, Microscopy, Electron, Scanning, Models, Statistical, osteoclast, Oxides, pH, phosphate, Phosphorus Compounds, physical chemistry, priority journal, prosthesis material, simulation, Spectrum Analysis, Raman, structure analysis, temperature, Time Factors, Titanium, weight reduction},
	isbn = {17427061 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33846874794\&partnerID=40\&md5=e8b44c423b36e42f43512d34157080ce},
	author = {Dias, A.G. and Gibson, I.R. and Santos, J.D. and Lopes, M.A.}
}
