



@article {2451,
	title = {Development of a system to adsorb drugs onto calcium phosphate materials},
	journal = {Journal of Materials Science: Materials in MedicineJ. Mater. Sci. Mater. Med.},
	volume = {16},
	year = {2005},
	note = {Cited By (since 1996): 6Export Date: 21 November 2012Source: ScopusCODEN: JSMMEdoi: 10.1007/s10856-005-2535-3PubMed ID: 15965596Language of Original Document: EnglishCorrespondence Address: Queiroz, A.C.; INEB - Instituto de Engenharia Biom{\'e}dica, Laborat{\'o}rio de Biomateriais, Rua do Campo Alegre 823, 4150-180, Porto, Portugal; email: aqueiroz@ineb.up.ptChemicals/CAS: ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; hydroxyapatite, 1306-06-5, 51198-94-8; metronidazole, 39322-38-8, 443-48-1; Ampicillin, 69-53-4; Anti-Infective Agents; calcium phosphate, 10103-46-5; Calcium Phosphates; Coated Materials, Biocompatible; Delayed-Action Preparations; Drug Carriers; Metronidazole, 443-48-1References: Seymour, R.A., Heasman, P.A., Macgregor, I.D.M., (1992) Drugs, Diseases, and the Periodontium, 1. , edited by R. A. Seymour and P. A. Heasman Oxford University Press, Oxford;Carnevale, R.A., Greco, G.W., Bullard, C.M., Hanker, J.S., (1987) Biomedical Materials and Devices, p. 247. , edited by J. S. Hanker and B. L. Giammara Materials Research Society, Pittsburgh; 
Friedman, M., Steinberg, D., (1990) Pharm. Res., 7, p. 313; 
Hagiwara, S., Takamatsu, N., Tominaga, Y., Umeda, M., (1998) J. Period., 69, p. 62; 
Wright, T.L., Ellen, R.P., Lacroix, J.M., Sinnadurai, S., Mittelman, M.W., (1997) J. Period. Res., 32, p. 473; 
Golomb, G., Friedman, M., Soskolne, A., Stabholz, A., Sela, M.N., (1984) J. Dent. Res., 63, p. 1149; 
Goodson, J.M., Hogan, P.E., Dunham, S.L., (1984) J. Period., 55, p. 81; 
Somayaji, B.V., Jariwala, U., Jayachandran, P., Vidyalakshim, K., Dudhani, R.V., (1998) J. Period., 69, p. 409; 
Stoltze, K., (1992) J. Clin. Period., 19, p. 698; 
Goodson, J.M., Holborow, D., Dunn, R.L., Hogan, P., Dunham, S., (1983) J. Period., 54, p. 575; 
Yu, D., Wong, J., Matsuda, Y., Fox, J.L., Higuchi, W.I., Otsuka, M., (1992) J. Pharm. Sci., 81, p. 529; 
Nishihara, K., (1993) Clin. Mater., 12, p. 159; 
Ferraz, M.P., Monteiro, F.J., Santos, J.D., (1999) J. Biomed. Mat. Res., 45, p. 376; 
Ferraz, M.P., Knowles, J.C., Olsen, I., Monteiro, F.J., Santos, J.D., (1999) J. Biomed. Mat. Res., 47, p. 603; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Ohtsuki, C., Osaka, A., Kaneko, S., Inoue, H., (2001) J. Biomed. Mat. Res., 54, p. 463; 
Queiroz, A.C., Santos, J.D., Monteiro, F.J., Gibson, I.R., Knowles, J.C., (2001) Biomaterials, 22, p. 1393; 
Santos, J.D., Knowles, J.C., Reis, R.L., Monteiro, F.J., Hastings, G.W., (1994) Biomaterials, 15, p. 5; 
Knowles, J.C., Santos, J.D., Hastings, G.W., World Patent, WO0068164 (1994)Myers, H.M., Tochon-Danguy, H.J., Baud, C.A., (1983) Calcif. Tissue Int., 35, p. 745; 
Ratier, A., Gibson, I.R., Best, S.M., Freche, M., Lacout, J.L., Rodrigues, F., (2001) Biomaterials, 22, p. 897; 
Ando, D.J., (1996) Ultraviolet and Visible Spectroscopy, p. 16. , John Wiley \& Sons, West Sussex
},
	month = {2005///},
	pages = {641 - 646},
	abstract = {Several studies were carried out in order to reduce the systemic use of antibiotics due to the high concentration required to provide the minimum inhibitory concentration (MIC) at infected sites. The aim of this study was to develop a system of drug adsorption onto commercial hydroxyapatite (HA, Ca                        10(PO
                        4)
                        6(OH)
                        2) and glass reinforced hydroxyapatite (GR-HA) granules. The drug will then be released for the local treatment of periodontitis. The antibiotics used in this study were metronidazole, a specific antibiotic indicated for the systemic treatment of periodontitis, and ampicillin, a wide spectrum antibiotic. UV spectroscopy was used to measure the amount of drug adsorbed onto HA and GR-HA granules. Results showed that metronidazole was unable to adsorb on the material{\textquoteright}s surface, as opposed to ampicillin which adsorbed both onto HA and GR-HA. Preliminary release kinetics studies were carried out using a flow through dissolution system. Results are discussed in terms of the influence of the different surface characteristics of the materials on the adsorption processes. {\textcopyright} 2005 Springer Science + Business Media, Inc.
},
	keywords = {Adsorption, ampicillin, Anti-Infective Agents, Antibiotics, article, Calcium Compounds, calcium phosphate, Calcium phosphates, Coated Materials, Biocompatible, concentration response, Delayed-Action Preparations, Diffusion, Dissolution, drug absorption, drug adsorption, Drug Carriers, Drug release, drug stability, glass, Glass reinforced hydroxyapatie (GR-HA), human, Humans, hydroxyapatite, Kinetics, Material{\textquoteright}s surface, Materials science, materials testing, metronidazole, minimum inhibitory concentration, Minimum inhibitory concentration (MIC), periodontitis, priority journal, Reaction kinetics, reduction, surface property, Ultraviolet spectroscopy},
	isbn = {09574530 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-21344438213\&partnerID=40\&md5=5963a17bf67c04ab22d05ce113fa12b0},
	author = {Queiroz, A.C. and Santos, J.D. and Monteiro, F.J.}
}
