



@article {2453,
	title = {Bone substitutes: General concepts and "state of the art"},
	journal = {Substitutos {\'o}sseos: Conceitos gerais e estado actualArquivos de MedicinaArq. Med.},
	volume = {19},
	year = {2005},
	note = {Export Date: 21 November 2012Source: ScopusCODEN: ARQMELanguage of Original Document: PortugueseCorrespondence Address: Gutierres, M.; Servi{\c c}o de Ortopedia, Hospital de S{\~a}o Jo{\~a}o, Alameda Prof. Hern{\^a}ni Monteiro, 4200-319 Porto, Portugal; email: m.gutierres@sapo.ptChemicals/CAS: calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; calcium sulfate, 13397-24-5, 23296-15-3, 7778-18-9; fibroblast growth factor, 62031-54-3; transforming growth factor, 76057-06-2References: Laurencin, C.T., Chapter I- Bone graft and bonegraft substitutes a brief history (2004) Bone Graft Substitute - ASTM International, , Laurencin CT, editors;Ratner, B.D., A history of Biomaterials (2004) Biomaterials Science. 2 nd Edition, pp. 10-19. , Ratner, edits. Elsevier Inc; 
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},
	month = {2005///},
	pages = {153 - 162},
	abstract = {Bone grafts are nowadays the subject of extensive research worldwide, aimed at overcoming limitations associated with the use of autografts or bone banks to fill bone defects. Additionally, the use of osteogenic substances opens new perspectives in the treatment of fractures, pseudarthroses and vertebral arthrodeses. Due to the large amount of information available in the area of bone grafts, this paper aims not only to revise general concepts but also to summarize what has been published recently in the area of bone substitutes for bone regeneration. {\textcopyright}ArquiMed, 2006.},
	keywords = {Autografts, biomaterial, bone defect, bone demineralization, bone development, Bone graft, Bone growth factors, Bone morphogenetic protein, bone prosthesis, calcium phosphate, calcium sulfate, cortical bone, fibroblast growth factor, fracture, health care facility, health status, human, hydroxyapatite, platelet derived growth factor, pseudarthrosis, publication, review, somatomedin C derivative, spondylarthritis, transforming growth factor},
	isbn = {08713413 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33748855173\&partnerID=40\&md5=494dbb696981df5711e7dda7d1393224},
	author = {Gutierres, M. and Ascens{\~a}o Lopes, M. and Sooraj Hussain, N. and Trigo Cabral, A. and Almeida, L. and Domingos Santos, J.}
}
