



@article {2458,
	title = {Bonelike{\textregistered}/PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation},
	journal = {Journal of Materials Science: Materials in MedicineJ. Mater. Sci. Mater. Med.},
	volume = {16},
	year = {2005},
	note = {Cited By (since 1996): 8Export Date: 21 November 2012Source: ScopusCODEN: JSMMEdoi: 10.1007/s10856-005-6687-yLanguage of Original Document: EnglishCorrespondence Address: Santos, J.D.; INEB - Inst. de Engenharia Biomedica, Laborat{\'o}rio de Biomateriais, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal; email: jdsantos@fe.up.ptChemicals/CAS: hydroxyapatite, 1306-06-5, 51198-94-8; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26124-68-5; cyclohexane, 110-82-7; methanol, 67-56-1; polyglactin, 26780-50-7, 34346-01-5; silane, 7803-62-5; water, 7732-18-5; Durapatite, 1306-06-5; Lactic Acid, 50-21-5; Polyglycolic Acid, 26009-03-0; polylactic acid-polyglycolic acid copolymer; Polymers; SilanesTradenames: Bonelike, AldrichManufacturers: AldrichReferences: Aoki, H., (1991) Science and Medical Applications of Hydroxyapatite, , JAAS;Glimcher, M.J., (1976) Handbook of Physiology, Endocrinology, , edited by R. O. Greep and E. B. Astwood (American Physiological Society, Washington D.C.); 
Shors, E.C., Holmes, R.E., (1993) An Introduction to Bioceramics, p. 181. , edited by L. L. Hench and J. Wilson (World Scientific, Hong-Kong); 
Santos, J.D., Knowles, J.C., Reis, R.L., Monteiro, F.J., Hastings, G.W., (1994) Biomaterials, 15, p. 5; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Knowles, J.C., (1998) J. Biomed. Mater. Res., 39, p. 244; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., (1999) J. Biomed. Mater. Res., 48, p. 734; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., (1999) Biomaterials, 20, p. 2085; 
Lopes, M.A., Silva, R.F., Monteiro, F.J., Santos, J.D., (2000) Biomaterials, 21, p. 749; 
Lopes, M.A., Knowles, J.C., Santos, J.D., (2000) Biomaterials, 21, p. 1905; 
Jha, L.J., Santos, J.D., Knowles, J.C., (1996) J. Biomed. Mater. Res., 31, p. 481; 
Ferraz, M.P., Fernandes, M.H., Santos, J.D., Monteiro, F.J., (2001) J. Mater. Sci.: Mater. Med., 12, p. 629; 
Lopes, M.A., Knowles, J.C., Santos, J.D., Monteiro, F.J., Olsen, I., (2000) Biomaterials, 21, p. 1165; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Ohtsuki, C., Osaka, A., Kaneko, S., Inoue, H., (2001) J. Biomed. Mater. Res., 54, p. 463; 
Wang, M., Deb, S., Bonfield, W., (2000) Mater. Lett., 44, p. 119; 
George, I., Viel, P., Bureau, C., Suski, J., L{\'e}cayon, G., (1996) Surf. Interf. Anal., 24, p. 774; 
Liu, Q., De Wijn, J.R., De Groot, K., Van Blitterwijk, C.A., (1998) Biomaterials, 19, p. 1067; 
Ara, M., Watanabe, M., Imai, Y., (2002) Biomaterials, 23, p. 2479; 
Agrawal, C.M., Ray, R.B., (2001) J. Biomed. Mater. Res., 55, p. 141; 
Arnold, U., Lindenhayn, K., Perka, C., (2002) Biomaterials, 23, p. 2303; 
Rizzi, S.C., Heath, D.J., Coombes, A.G.A., Bock, N., Textor, M., Downes, S., (2001) J. Biomed. Mater. Res., 55, p. 475; 
Simon Jr., C.G., Khatri, C.A., Wight, S.A., Wang, F.W., (2002) J. Orthop. Res., 20, p. 473; 
Mikos, A.G., Temenoff, J.S., (2000) EJB Electr. J. Biotechn., 3 (2); 
Laurencin, C.T., Attawia, M.A., Lu, L.Q., Borden, M.D., Lu, H.H., Gorum, W.J., Lieberman, J.R., (2001) Biomaterials, 22, p. 1271; 
Takenaga, M., Yamaguchi, Y., Kitagawa, A., Ogawa, Y., Mizushima, Y., Igarashi, R., (2002) J. Contr. Rel., 79, p. 81; 
Dupraz, A.M.P., De Wijn, J.R., Van De Meer, S.A.T., De Groot, K., (1996) J. Biomed. Mater. Res., 30, p. 231; 
Sheldon, R.P., (1982) Appl. Sci. Publ., 1, p. 1; 
Zhu, P.X., Ishikawa, M., Seo, W.S., Hozumi, A., Yokogawa, Y., Koumoto, K., (2002) J. Biomed. Mater. Res., 59, p. 294; 
Hooshmand, T., Van Noort, R., Keshvad, A., (2002) Dent. Mater., 18, p. 179; 
Venhoven, B.A.M., De Gee, A.J., Werner, A., Davidson, C.L., (1994) Biomaterials, 15, p. 1152; 
Yerby, S.A., Paal, A.F., Young, P.M., Beaupr{\'e}, G.S., Ohashi, K.L., Goodman, S.B., (2000) J. Biomed. Mater. Res., 49, p. 127; 
Wang, M., Bonfield, W., (2001) Biomaterials, 22, p. 1311; 
Santos, C., Luklinska, Z.B., Clarke, R.L., Davy, K.W.M., (2001) J. Mater. Sci.: Mat. Med., 12, p. 565; 
Santos, J.D., Knowles, J.C., Hastings, G.W., in "Sintered Hydroxyapatite Compositions and Method for the Preparation Thereof," European Patent No. WO0068164 (2000)Afonso, A., Santos, J.D., Vasconcelos, M., Branco, R., Cavalheiro, J., (1996) J. Mater. Sci.: Mater. Med., 7, p. 507; 
Hoffman, R., Westheim, J.G.F., Pouwel, I., Fransen, T., Gellings, P.J., (1996) Surf. Interf. Anal., 24, p. 1; 
Rider, A.N., Arnott, D.R., (1996) Surf. Interf. Anal., 24, p. 583; 
Eufinger, S., Van Ooij, W.J., Conners, K.D., (1996) Surf. Interf. Anal., 24, p. 841
},
	month = {2005///},
	pages = {253 - 259},
	abstract = {Bonelike{\textregistered}/PLGA hybrid materials have been developed using γ-MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike{\textregistered}, and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent (P method), a much thinner film was achieved. Functional groups of PLGA, such as the carbonyl group (C=O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules. {\textcopyright} 2005 Springer Science + Business Media, Inc.},
	keywords = {analytic method, article, Biological materials, Bone, Bone Regeneration, carbonyl derivative, chemical bond, chemical interaction, chemical reaction, Chemical reactions, chemistry, Chemistry, Physical, cyclohexane, Drug delivery, drug delivery system, Drug therapy, Durapatite, film, Fourier transform infrared spectroscopy, Hybrid materials, hybridization, hydroxyapatite, infrared spectroscopy, Lactic Acid, methanol, methodology, Microscopy, Electron, Scanning, Molecules, physical chemistry, polyglactin, polyglycolic acid, polylactic acid polyglycolic acid copolymer, polylactic acid-polyglycolic acid copolymer, polymer, Polymers, priority journal, Raman spectrometry, Raman spectroscopy, reaction analysis, Scanning electron microscopy, silane, silane derivative, Silanes, Silanization, solvent effect, Solvents, Spectroscopy, Fourier Transform Infrared, Spectrum Analysis, Raman, synthesis, Water, X ray, X-Rays},
	isbn = {09574530 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-15244353590\&partnerID=40\&md5=55644ee9e5b6fa323ca5693fafe0d8d7},
	author = {Oliveira, J.M. and Miyazaki, T. and Lopes, M.A. and Ohtsuki, C. and Santos, J.D.}
}
