



@article {2475,
	title = {Laser surface modification of hydroxyapatite and glass-reinforced hydroxyapatite},
	journal = {BiomaterialsBiomaterials},
	volume = {25},
	year = {2004},
	note = {Cited By (since 1996): 12Export Date: 21 November 2012Source: ScopusCODEN: BIMADdoi: 10.1016/j.biomaterials.2003.11.054PubMed ID: 15120506Language of Original Document: EnglishCorrespondence Address: Queiroz, A.C.; INEB-Inst. de Engenharia Biomedica, Laborat{\'o}rio de Biomateriais, Rua do Campo Alegre 823, 4150-180, Porto, Portugal; email: aqueiroz@ineb.up.ptChemicals/CAS: hydroxyapatite, 1306-06-5, 51198-94-8; Biocompatible Materials; Durapatite, 1306-06-5; Macromolecular SubstancesReferences: Krejci, C.B., Bissada, N.F., Farah, C., Greenwell, H., Clinical evaluation of porous and nonporous hydroxyapatite in the treatment of human periodontal bony defects (1987) J Periodontol, 58, pp. 521-528;Seymour, R.A., Heasman, P.A., MacGregor, I.D.M., The pathogenesis of periodontal disease (1992) Drugs, Diseases, and the Periodontium, pp. 1-10. , I.D.M. MacGregor. Oxford: Oxford University Press; 
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},
	month = {2004///},
	pages = {4607 - 4614},
	abstract = {Surface treatment of materials with excimer laser radiation often results in the formation of a rough columnar or cone-shaped surface topography, which leads to a considerable increase in the surface area. As a result, the search for a non-porous bioactive material with adequate mechanical properties and a high surface to volume ratio, similar to porous materials, which could be used for drug delivery in the treatment of periodontitis, justified assessing excimer laser surface treatment to promote controlled roughning of hydroxyapatite (HA) and glass-reinforced hydroxyapatite (GR-HA). A KrF excimer laser with 248nm radiation wavelength and 30ns pulse duration was used for surface modification. The laser treatment was carried out in air, using wide ranges of radiation fluence and number of laser pulses. In order to identify the physico-chemical changes induced by the laser treatment and the column formation mechanisms in these materials, the treated surfaces were characterised by laser profilometry, scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infra-red spectroscopy (FTIR). Laser processing induced the formation of a surface topography consisting of cone-shaped features. The constitution of the surface layer was also modified, as revealed by FTIR, XPS and XRD. This work has shown that laser surface modification increases the surface area of HA and GR-HA and is a promising technique to increase the reactivity and drug delivery capability of both materials. {\textcopyright} 2003 Elsevier Ltd. All rights reserved.},
	keywords = {article, Biocompatible Materials, Biomaterials, drug delivery system, Durapatite, Excimer laser, Excimer lasers, Fourier transform infrared spectroscopy, FTIR, glass, hydroxyapatite, infrared spectroscopy, laser, Lasers, Macromolecular Substances, materials testing, Molecular Conformation, Non-porous bioactive materials, periodontitis, physical chemistry, porosity, priority journal, Profilometry, Radiation Dosage, Reinforcement, Scanning electron microscopy, Surface area, Surface modification, Surface Properties, Surface treatment, topography, X ray diffraction, X ray diffraction analysis, X ray photoelectron spectroscopy, XPS, XRD},
	isbn = {01429612 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-2342427815\&partnerID=40\&md5=24da3c08c0c7b636d9d5039812944b52},
	author = {Queiroz, A.C. and Santos, J.D. and Vilar, R. and Eug{\'e}nio, S. and Monteiro, F.J.}
}
