



@article {2481,
	title = {Inflammatory responses and cell adhesion to self-assembled monolayers of alkanethiolates on gold},
	journal = {BiomaterialsBiomaterials},
	volume = {25},
	year = {2004},
	note = {Cited By (since 1996): 34Export Date: 21 November 2012Source: ScopusCODEN: BIMADdoi: 10.1016/j.biomaterials.2003.09.047PubMed ID: 14751741Language of Original Document: EnglishCorrespondence Address: Barbosa, J.N.; INEB - Inst. de Engenharia Biomedica, Laborat{\'o}rio de Biomaterials, Rua do Campo Alegre 823, 4150-180 Porto, Portugal; email: judite@ibmc.up.ptChemicals/CAS: Gold, 7440-57-5; Sulfhydryl CompoundsReferences: Tang, L., Jiang, W., Welty, S.E., The participation of P- and E-selectins on biomaterial-mediated tissue responses (2002) J Biomed Mater Res, 62, pp. 471-477;Thomsen, P., Gretzer, C., Macrophage interactions with modified material surfaces (2001) Curr Opin Solid State Mater Sci, 5, pp. 163-176; 
Kao, W.J., Liu, Y., Gundloori, R., Li, J., Lee, D., Einerson, N., Burmania, J., Stevens, K., Engineering endogenous inflammatory cells as delivery vehicles (2002) J Control Release, 78, pp. 219-233; 
Anderson, J.M., Mechanisms of inflammation and infection with implanted devices (1993) Cardiovasc Pathol, 2, pp. 33S-41S; 
Anderson, J.M., Inflammatory response to implants (1988) ASAIO J, 11, pp. 101-107; 
Babensee, J.E., Anderson, J.M., McLntire, L.V., Mikos, A.G., Host response to tissue engineered devices (1998) Adv Drug Deliver Rev, 33, pp. 111-139; 
Mrksich, M., Whitesides, G.M., Interactions of SAMs with proteins (1996) Annu Rev Biophys Biomol Struct, 25, pp. 55-57; 
Ulman, A., Formation and structure of self-assembled monolayers (1996) Chem Rev, 96, pp. 1533-1554; 
Mrksich, M., Tailored substrates for studies of attached cell culture (1998) Cell Mol Life Sci, 54, pp. 653-662; 
Nuzzo, R.G., Allara, D.L., Adsorption of biofunctional organic dissulfides on gold surfaces (1983) J Am Chem Soc, 105, pp. 4481-4483; 
Pan, S., Castner, D.G., Ratner, B.D., Multitechnique surface characterization of derivatization efficiencies for hydroxyl-terminated self-assembled monolayers (1998) Langmuir, 14, pp. 3545-3550; 
Sedwick, A.D., Sin, Y.M., Edwards, J.C., Willoughby, D.A., Increased inflammatory reactivity in newly formed lining tissue (1983) J Pathol, 141, pp. 483-495; 
Castro, A.G., Esaguy, N., MacEdo, P.M., {\'A}guas, A.P., Silva, M.T., Live but not heat-killed mycobacteria cause rapid chemotaxis of large numbers of eosinophils in vivo and are ingested by the attracted granulocytes (1991) Infect Immun, 59, pp. 3009-3014; 
Isaji, M., Momose, Y., Naito, J., Enhancement of inflammatory reactions in a non-immunological air pouch model in rats (1989) Br J Exp Pathol, 70, pp. 705-716; 
Tegoulia, V.A., Cooper, S.L., Leukocyte adhesion on model surfaces under flow: Effects of surface chemistry, protein adsorption, and shear rate (2000) J Biomed Mater Res, 50, pp. 291-301; 
Lin, J., Chuang, W., Synthesis, surface characterization, and platelet reactivity evaluation for the self-assembled monolayer of alkanethiol with sulfonic acid functionality (2000) J Biomed Mater Res, 51, pp. 413-423; 
Hooper, K.A., Nickolas, T.L., Yurkow, E.J., Kohn, J., Laskin, D., Characterization of the inflammatory response to biomaterials using a rodent air pouch model (2000) J Biomed Mater Res, 50, pp. 365-374; 
Wooley, P.H., Morren, R., Andary, J., Sud, S., Yang, S., Mayton, L., Markel, D., Nasser, S., Inflammatory responses to orthopaedic biomaterials in the murine air pouch (2002) Biomaterials, 23, pp. 517-526; 
Gelb, H., Schumacher, H.R., Cuckler, J., Ducheyne, P., Baker, D.G., In vivo inflammatory response to polymethylmethacrylate particulate debris: Effect of size, morphology, and surface area (1994) J Orthop Res, 12, pp. 83-92; 
Wooley, P.H., Mayton, L., Sud, S., Nasser, S., Synergistic inflammatory responses to metallic and polymeric particles in the murine air pouch model of aseptic loosening (1996) Arthritis Rheum, 39, pp. 175-183; 
Moore, R., Beredjiklian, P., Rhoad, R., Theiss, S., Cuckler, J., Ducheyne, P., Baker, D.G., A comparison of the inflammatory potential of particulates derived from two composite materials (1997) J Biomed Mater Res, 34, pp. 137-147; 
Krause, T.J., Robertson, F.M., Greco, R.S., Measurement of intracellular hydrogen peroxide induced by biomaterials implanted in a rodent air pouch (1993) J Biomed Mater Res, 27, pp. 65-69; 
Yang, S., Ren, W., Park, Y., Sieving, A., Hsu, S., Nasser, S., Wooley, P.H., Diverse cellular and apoptotic responses to variant shapes of UHMWPE particles in a murine model of inflammation (2002) Biomaterials, 23, pp. 3535-3543; 
Lindblad, M., Lestelius, M., Johansson, A., Tengvall, P., Thomsen, P., Cell and soft tissue interactions with methyl- and hydroxyl-terminated alkanethiols on gold surfaces (1997) Biomaterials, 18, pp. 1059-1068; 
Tengvall, P., Askendal, A., Lundsr{\"o}m, I., Complement activation by 3-mercapto-1,2-propanediol immobilized on gold surfaces (1996) Biomaterials, 17, pp. 1001-1007; 
Liu, L., Elwing, H., Complement activation on thiol-modified gold surfaces (1996) J Biomed Mater Res, 30, pp. 535-541; 
Tang, L., Liu, L., Elwing, H.B., Complement activation and inflammation triggered by model biomaterial surfaces (1998) J Biomed Mater Res, 41, pp. 333-340; 
K{\"a}lltorp, M., Oblogina, S., Jacobsson, S., Karlsson, A., Tengvall, P., Thomsen, P., In vivo cell recruitment, cytokine release and chemiluminescence response at gold, and thiol functionalized surfaces (1999) Biomaterials, 20, pp. 2123-2137; 
Tang, L., Ugarova, T.P., Plow, E.F., Eaton, J.W., Molecular determinants of acute inflammatory responses to biomaterials (1997) J Clin Invest, 97, pp. 1329-1334; 
Hu, W., Eaton, J.W., Tang, L., Molecular basis of biomaterial-mediated foreign body reactions (2001) Blood, 98, pp. 1231-1238; 
Silver, J.H., Hergenrother, R.W., Lin, J., Lim, F., Lin, H., Okada, T., Chaudhury, M.K., Cooper, S.L., Surface and blood-contacting properties of alkylsiloxane monolayers supported on silicone rubber (1995) J Biomed Mater Res, 29, pp. 535-548; 
Werth{\'e}n, M., Sellborn, A., K{\"a}lltorp, M., Elwing, H., Thomsen, P., In vitro study of monocyte viability during the initial adhesion to albumin- and fibrinogen-coated surfaces (2001) Biomaterials, 22, pp. 827-832; 
Tang, L., Eaton, J.W., Fibrin(ogen) mediates acute inflammatory responses to biomaterials (1993) J Exp Med, 178, pp. 2147-2156; 
Liu, L., Elwing, H., Complement activation on solid surfaces as determined by C3 deposition and hemolytic consumption (1994) J Biomed Mater Res, 28, pp. 767-773; 
Tengvall, P., Askendal, A., Lundstrom, I., Complement activation by IgG immobilized on methylated silicon (1996) J Biomed Mater Res, 31, pp. 305-312; 
K{\"a}lltorp, M., Askendal, A., Thomsen, P., Tengvall, P., Ellipsometric studies in vitro on kinetics of rat complement activation (1999) J Biomed Mater Res, 44, pp. 222-225; 
Barbosa, J.N., Barbosa, M.A., {\'A}guas, A.P., Adhesion of human leukocytes to biomaterials: An in vitro study using alkanethiolate monolayers with different chemically functionalized surfaces (2003) J Biomed Mater Res, 65, pp. 429-434
},
	month = {2004///},
	pages = {2557 - 2563},
	abstract = {The acute inflammatory response and the adhesion of cells to self-assembled monolayers (SAMs) of well-defined surface chemistry was studied in vivo using a rodent air-pouch model of inflammation. SAMs with three different terminal functional groups (OH, COOH and CH                        3) were implanted in subcutaneous air pouches induced in BALB/c mice. After 24h, inflammatory cells were recovered from the air pouches and the implants were removed and prepared for observation by scanning electron microscopy (SEM). The implants coated with OH and CH
                        3, were found to cause the highest recruitment of inflammatory cells into the subcutaneous pouches. Polymorphonuclear neutrophils (PMNs) leukocytes predominated over mononuclear cells in inflammatory exudates of SAMs-coated implants, the opposite being found in uncoated implants (controls). CH
                        3-coated implants induced the highest number of inflammatory cells and also the largest percentage of PMNs seen in the subcutaneous pouches. Control and OH-covered implants presented the higher densities of attached inflammatory cells detected by SEM. In contrast, the CH
                        3-coated implants showed a very low density of cells adherent to the implant surface. We conclude that the chemical nature and the degree of hydrophobicity of the surface of implants modulate both the local acute inflammatory reaction and the adhesion of leukocytes. {\textcopyright} 2003 Elsevier Ltd. All rights reserved.
},
	keywords = {Air-pouch model, alkane derivative, animal cell, animal experiment, animal model, Animals, article, Biomaterials, cell adhesion, Cell culture, cell density, cell surface, Cell-surface interactions, controlled study, exudate, gold, gold complex, hydrophobicity, implantation, Inflammation, Inflammatory responses, leukocyte, Leukocytes, male, material coating, Mice, Mice, Inbred BALB C, Microscopy, Electron, Scanning, mouse, neutrophil, nonhuman, polymorphonuclear cell, priority journal, Rodentia, Scanning electron microscopy, Self assembly, Self-assembled monolayers, Sulfhydryl Compounds, Surface chemistry, surface property},
	isbn = {01429612 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324843\&partnerID=40\&md5=4fc63f7a8a6d1c445f0be27356884543},
	author = {Barbosa, J.N. and Barbosa, M.A.A. and {\'A}guas, A.P.}
}
