



@article {2519,
	title = {Dissolution studies of hydroxyapatite and glass-reinforced hydroxyapatite ceramics},
	journal = {Materials CharacterizationMater Charact},
	volume = {50},
	year = {2003},
	note = {Conference code: 61615Cited By (since 1996): 15Export Date: 21 November 2012Source: ScopusCODEN: MACHEdoi: 10.1016/S1044-5803(03)00092-5Language of Original Document: EnglishCorrespondence Address: Prado da Silva, M.H.; DEMP, UFC, Campus PICI, Bl. 714, Fortaleza, CE 60455-760, Brazil; email: mhprado@dem.ufc.brReferences: Barinov, S.M., Baschenko, Y.V., Application of ceramic composites as implants: Result and problem (1992) Bioceramics and the Human Body, pp. 206-210. , A. Ravaglioli, \& A. Krajewski. United Kingdom: Elsevier;Nishihara, K., Studies on peri-root tissue formation around new type artificial root made of dense hydroxyapatite (1993) Clin. Mater., 12, pp. 159-167; 
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Ferraz, M.P., Knowles, J.C., Olsen, I., Monteiro, F.J., Santos, J.D., Flow cytometry analysis of effects of glass on response of osteosarcoma cells to plasma-sprayed hydroxyapatite/CaO-P 2O 5 coatings (1999) J. Biomed. Mater. Res., 47, pp. 603-611; 
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Lopes, M.A., Santos, J.D., Monteiro, F.J., Ohtsuki, C., Osaka, A., Kaneko, S., Push-out testing and histological evaluation of glass reinforced hydroxyapatite composites implanted in the tibia of rabbits (2001) J. Biomed. Mater. Res., 54, pp. 463-469; 
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Klein, C.P.A.T., Wolke, J.G.C., De Blieck-Hogervorst, J.M.A., De Groot, K., Calcium phosphate plasma-sprayed coatings and their stability: An in vivo study (1994) J. Biomed. Mater. Res., 28, pp. 909-917; 
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},
	month = {2003///},
	pages = {197 - 202},
	address = {Rio de Janeiro},
	abstract = {In the continuous agitation assays, glass-reinforced hydroxyapatite (GR-HA) was shown to form a calcium phosphate (CaP) layer, but hydroxyapatite (HA) only formed dispersed precipitates. The formation of this layer was first detected on the GR-HA with a 7.5\% glass addition (7.5 GR-HA) after only 3 days of immersion in simulated body fluid (SBF). The time required for layer formation decreased as the amount of glass added to the HA increased. The dissolution rate of the materials followed a similar pattern, i.e. the dissolution rate for GR-HA was higher than for HA, and increased with the addition of glass. The immersion of 7.5 GR-HA in water showed almost linear dissolution kinetics over the immersion periods (3, 7, 15, 30 and 60 days). The concentration of calcium ions in solution and the scanning electron microscopy (SEM) analysis of the 7.5 GR-HA specimens immersed in water and in SBF revealed a clear competition between the material dissolution and the precipitation of a CaP phase. Fourier transformed infrared spectroscopy with alternated total reflectance (FTIR-ATR) analysis indicated that the CaP phase that formed during longer immersion times (30 and 60 days) could be a carbonate-substituted CaP precipitate. As expected from previous work, the GR-HA behavior in terms of its in vitro bioactivity is higher than HA because a homogeneous CaP layer is formed and the precipitation occurs faster. From the dissolution test and in accordance with the chemical composition of the samples, GR-HA was more soluble than HA. {\textcopyright} 2003 Elsevier Inc. All rights reserved.},
	keywords = {Ceramic materials, Dissolution, glass, Glass-reinforced hydroxyapatite, hydroxyapatite, Immersion times, Scanning electron microscopy},
	isbn = {10445803 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0141895021\&partnerID=40\&md5=9226464f75e2ecd20d23f9d42e61d69e},
	author = {Queiroz, A.C. and Santos, J.D. and Monteiro, F.J. and Prado da Silva, M.H.},
	editor = {Solorzano G. and Freire Jr. F.L. and Soares G.A. and Souza P.L.}
}
