



@article {2537,
	title = {Cellulose phosphates as biomaterials. II. Surface chemical modification of regenerated cellulose hydrogels},
	journal = {Journal of Applied Polymer ScienceJ. Appl. Polym. Sci.},
	volume = {82},
	year = {2001},
	note = {Cited By (since 1996): 16Export Date: 21 November 2012Source: ScopusCODEN: JAPNAdoi: 10.1002/app.2194Language of Original Document: EnglishCorrespondence Address: Granja, P.L.; Laborat{\'o}rio de Biomaterials, Instituto de Engenharia Biomedica, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal; email: pgranja@ibmc.up.ptReferences: Williams, D.F., (1995) Med Der Technol, 6, p. 6;Gebelein, C.G., (1990) Biomimetic Polymers, , Plenum Press: New York; 
Hoffman, A.S., (1996) Biomaterials Science: An Introduction to Materials in Medicine, p. 124. , Ratner, B. D.; Hoffman, A. S.; Schoen, F. J.; Lemons, J. F., Eds.; Academic Press: San Diego, Chapter 2; 
Kasemo, B., Lausmaa, J., (1995) Environ Health Perspect, 102, p. 41; 
Ratner, B.D., (1980) J Biomed Mater Res, 14, p. 665; 
Poustis, J., Baquey, C., Chauveaux, D., (1994) Clin Mater, 16, p. 119; 
Gross, U., M{\"u}ller-Mai, C., Voigt, C., (1992) Proceedings of the 4th World Biomaterials Congress, p. 192. , The Tissue Response on Cellulose Cylinders After Implantation in the Distal Femur of Rabbits, Berlin, Germany, April; 
Baquey, C., Barbi{\'e}, C., More, N., Rouais, F., Poustis, J., Chauveaux, D., (1992) Proceedings of the 4th World Biomaterials Congress, p. 365. , In Vivo Study of the Bio-Stability of a Cellulose Material, Berlin, Germany, April; 
Chauveaux, D., Barbi{\'e}, C., Barthe, X., Baquey, C., Poustis, J., (1990) Clin Mater, 5, p. 251; 
Pommier, J.C., Poustis, J., Baquey, C., Chauveaux, D., Fr. Demande 8610331. 1986Eur. Pat. 0256906 A1, 1987U.S. Pat. 4,904,258, 1990Imbert, E., Letourneur, D., Jozefowicz, M., (1997) J Biomed Mater Res, 34, p. 417; 
Dowd, V., Yon, R.J., (1992) J Chromatogr, 627, p. 145; 
Kennedy, J.F., Cabral, J.M.S., (1983) Solid Phase Biochemistry: Analytical Synthetic Aspects, p. 253. , Scoutch, W. H., Ed. Wiley: New York, Chapter 7; 
Sugihara, J., Imamura, T., Yanase, T., (1982) J Chromatogr, 229, p. 193; 
Shih, T.Y., Martin, M.A., (1974) Biochemistry, 13, p. 3411; 
Holmquist, W.R., Schroeder, W.A., (1967) J Chromatogr, 26, p. 465; 
Thomaidis, T.S., Fidalgo, B.V., Harshman, S., Najjar, V.A., (1967) Biochemistry, 6, p. 3369; 
Granja, P.L., Pouys{\'e}gu, L., P{\'e}traud, M., De J{\'e}so, B., Baquey, C., Barbosa, M.A., (2001) J Appl Polym Sci, 82, p. 3341; 
Granja, P.L., Barbosa, M.A., Pouys{\'e}gu, L., De J{\'e}so, B., Baquey, C., (1999) Frontiers in Biomedical Polymers Applications, 2, p. 195. , Ottenbrite, R., Ed. Technomic Press: Lancaster, PA; 
Granja, P.L., Baquey, C., Pouys{\'e}gu, L., Bareille, R., De J{\'e}so, B., Barbosa, M.A., (1996) Polymers in Medicine and Surgery, PIMS{\textquoteright}96, p. 73. , Glasgow, UK; 
Klemm, D., Philipp, B., Heinze, T., Heinze, U., Wagenknecht, W., (1998) Comprehensive Cellulose Chemistry: Fundamentals and Analytical Methods, 1, p. 9. , Wiley-VCH Verlag: Weinheim, Germany, Chapter 2; 
Zeronian, S.H., (1985) Cellulose Chemistry and Its Applications, p. 159. , Nevell, T.P. Zeronian, S.H., Eds. Ellis Horwood: Chichester, UK, Chapter 6; 
Granja, P.L., Pouys{\'e}gu, L., De J{\'e}so, B., Rouais, F., Baquey, C., Barbosa, M.A., J Appl Polym Sci, , to appear; 
Ratner, B.D., Castner, D., (1997) Surface Analysis: The Principal Techniques, p. 43. , Vickerman, J.C., Ed. Wiley: Chichester, UK, Chapter 3; 
Dupraz, A., Nguyen, T.-P., Richard, M., Daculsi, G., Passuti, N., (1999) Biomaterials, 20, p. 663; 
Nguyen, T.-P., Dupraz, A., (1996) J Biomater Sci Polym Ed, 8, p. 141; 
Hanawa, T., Ota, M., (1991) Biomaterials, 12, p. 767; 
Morra, M., Volpe, C.D., (1998) J Biomed Mater Res, 42, p. 473; 
Garbassi, F., Morra, M., Occhiello, E., (1994) Polymer Surfaces: From Physics to Technology, p. 161. , Wiley: New York, Chapter 4; 
Vogler, E.A., (1993) Surfactant Science Series 49 (Wettability), p. 183. , Marcel Dekker: New York; 
Good, R.J., (1992) J Adhes Sci Technol, 6, p. 1269; 
Good, R.J., (1979) Surface and Colloid Science, 11, p. 1. , Good, R.J. Stromberg, R.R., Eds. Plenum Press: New York; 
Von Recum, A.F., Brown, C.E., Shannon, C.E., LaBerge, M., (1999) Handbook of Biomaterials Evaluation: Scientific, Technical, and Clinical Testing of Implant Materials, 2nd ed., p. 227. , von Recum, A.F., Ed. Edwards Brothers: Ann Arbor, MI, Chapter 13; 
Boyan, B.D., Batzer, R., Kieswetter, K., Liu, Y., Cochran, D.L., Szmuckler-Moncler, S., Dean, D.D., Schwartz, Z., (1998) J Biomed Mater Res, 39, p. 77; 
Richards, R.G., (1996) Injury, 27, pp. SC38; 
Brunette, D.M., (1988) Surface Characterization of Biomaterials, p. 203. , Ratner, B.D., Ed. Elsevier Science: Amsterdam; 
Kuptsov, A.H., Zhizhin, G.N., (1998) Handbook of Fourier Transform Raman and Infrared Spectra of Polymers, Physical Series Data, 45. , Elsevier: Amsterdam; 
Nyquist, R.A., Craver, C.D., (1977) The Coblentz Society Desk Book of Infrared Spectra, p. 399. , Craver, C.D., Ed. The Coblentz Society: French Village, MO; 
Nakamoto, K., (1977) Infrared and Raman Spectra of Inorganic and Coordination Compounds, 3rd ed., , Wiley-Interscience: New York; 
Klemm, D., Philipp, B., Heinze, T., Heinze, U., Wagenknecht, W., (1998) Comprehensive Cellulose Chemistry: Fundamentals and Analytical Methods, 1, p. 181. , Wiley-VCH Verlag: Weinheim, Germany, Chapter 3; 
Matthews, I.P., Gibson, C., Samuel, A.H., (1994) Clin Mater, 15, p. 191; 
Chamberlain, V.C., Lambert, B., Tang, F.-W., (1999) Handbook of Biomaterials Evaluation: Scientific, Technical, and Clinical Testing of Implant Materials, p. 253. , von Recum, A.F., Ed. Taylor \& Francis: Philadelphia, Chapter 15; 
Phillips, G.O., Arthur J.C., Jr., (1985) Cellulose Chemistry and Its Applications, p. 290. , Nevell, T.P. Zeronian,S.H., Eds.; Ellis Horwood: Chichester, UK, Chapter 12; 
Ahmed, A.U., Rapson, W.H., (1972) J Polym Sci Part A Polym Chem, 10, p. 1945; 
Canet, D., (1996) Nuclear Magnetic Resonance: Concepts and Methods, , Wiley: Chichester, UK; 
Vogel, J., Russel, C., Gunther, G., Hartmann, P., Vizethum, F., Bergner, N., (1996) J Mater Sci Mater Med, 7, p. 495; 
Wu, Y., Glimcher, M.J., Rey, C., Ackerman, J.L., (1994) J Mol Biol, 244, p. 423; 
Rothwell, W.P., Waugh, J.S., Yesinowski, J.P., (1980) J Am Chem Soc, 102, p. 2637; 
Yokogawa, Y., Paz Reyes, J., Mucalo, M.R., Toriyama, M., Kawamoto, Y., Suzuki, T., Nishizawa, K., Kamayama, T., (1997) J Mater Sci Mater Med, 8, p. 407
},
	month = {2001///},
	pages = {3354 - 3365},
	abstract = {Cellulose regenerated by the viscose process was previously investigated as an implantable material in orthopedic surgery. It was envisaged to take advantage not only of its good matching with mechanical properties of bone but also of its hydroexpansivity, therefore allowing a satisfactory fixation to hard tissue. Both the osteoconduction and the lack of ostcoinduction of this material were demonstrated. Grafting of phosphate groups was then envisaged as the means to render cellulose more suitable for orthopedic applications by enhancing its bioactivity. In the present work, the previously optimized phosphorylation reaction was successfully adapted to the surface modification of regenerated cellulose. Modified materials were characterized by XPS, FTIR, and                        31P MAS NMR spectroscopic studies, and contact angle measurements, revealing the chemical bond between phosphate groups and cellulose, as well as the hydrophilic nature of phosphorylated materials, which increases with increasing phosphate contents. Water swelling and resistance to gamma sterilization were assessed as well, showing that phosphorylated materials swell considerably in water and were not affected when sterilization was carried out under a nitrogen atmosphere. The increase in surface roughness attributed to chemical modification was demonstrated through laser rugosimetry measurements. {\textcopyright} 2001 John Wiley \&amp; Sons, Inc. J. Appl. Polym. Sci.
},
	keywords = {2O, 3PO, 4/hexanol method, 4/P, 5/Et, Biomaterials, Cellulose derivatives, Cellulose phosphates, Chemical bonds, Chemical modification, Energy dispersive spectroscopy, Fourier transform infrared spectroscopy, H, Hydrogels, Phosphorylation, Regenerated cellulose hydrogels, Sterilization (cleaning), Surface modification, Surface roughness, X ray photoelectron spectroscopy},
	isbn = {00218995 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0035923980\&partnerID=40\&md5=5663bc99f91ce47534779e826f87ed97},
	author = {Granja, P.L. and Pouysgu, L. and Ptraud, M. and De Jso, B. and Baquey, C. and Barbosa, M.A.}
}
