



@article {2544,
	title = {Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite composites},
	journal = {BiomaterialsBiomaterials},
	volume = {22},
	year = {2001},
	note = {Cited By (since 1996): 55Export Date: 21 November 2012Source: ScopusCODEN: BIMADdoi: 10.1016/S0142-9612(00)00296-9PubMed ID: 11336313Language of Original Document: EnglishCorrespondence Address: Knowles, J.C.; Department of Biomaterials, Eastman Dental Institute, University College London, 256 Gray{\textquoteright}s Inn Road, London WC1X 8LD, United Kingdom; email: j.knowles@eastman.ucl.ac.ukChemicals/CAS: Ampicillin, 69-53-4; Durapatite, 1306-06-5; PenicillinsManufacturers: Plasma Biotal, United KingdomReferences: Farag, S.A., Simultaneous liquid chromatographic analysis of the β-lactam antibiotics cefazolin, cefadroxil, cepalexin, ampicillin, and cephradine in solution (1998) J AOAC Int, 81, pp. 381-385;Somayaji, B.V., Jariwala, U., Jayachandran, P., Vidyalakshmi, K., Dudhani, R.V., Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system (1998) J Periodontol, 69, pp. 409-413; 
Soskolne, W.A., Heasman, P.A., Stabholz, A., Smart, G.J., Palmer, M., Flashner, M., Newman, H.N., Sustained local delivery of chlorhexidine in the treatment of periodontitis; a multi-center study (1997) J Periodontol, 68, pp. 32-38; 
Steinberg, D., Friedman, M., Soskolne, A., Sela, M.N., A new degradable controlled release device for treatment of periodontal disease; in vitro release study (1990) J Periodontol, 61, pp. 393-398; 
Stoltze, K., Concentration of metronidazole in periodontal pockets after application of a metronidazole 25\% dental gel (1992) J Clin Periodontol, 19, pp. 698-701; 
Ramaglia, L., Sbordone, L., Lenci, F., Gulletta, E., Amato, G., Kennedy, E.B., Microbiology of porous hydroxylapatite implants in human periodontal osseous defects (1986) Biomaterials and clinical applications, 7 vol., pp. 675-680. , Pizzoferrate A., Marachetti P.G., Ravaglioli A., Lee A.J.C. (Eds.), Netherlands: Elsevier; 
Wilson, J., Low, S., Fetner, A., Hench, L.L., Bioactive materials for periodontal treatment; a comparative study (1986) Biomaterials and clinical applications, 7 vol., pp. 223-228. , Pizzoferrate A., Marachetti P.G., Ravaglioli A., Lee A.J.C. (Eds.), Netherlands: Elsevier; 
Kenney, E.B., Lekovic, V., Sa Ferreira, J.C., Han, T., Dimitrijavic, B., Carranza F.A. Jr, Bone formation within porous hydroxyapatite implants in human periodontal defects (1986) J Periodontol, 57, pp. 76-83; 
Krejei, C.B., Bissada, N.F., Farah, C., Greenwell, H., Clinical evaluation of porous and nonporous hydroxyapatite in treatment of human periodontal bony defects (1987) J Periodontol, 58, pp. 521-528; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., Serro, A.P., Saramago, B., Hydrophobicity, surface tensions, and zeta potential measurements of glass-reinforced hydroxyapatite composites (1999) J Biomed Mater Res, 45, pp. 370-375; 
Santos, J.D., Silva, P.L., Knowles, J.C., Talal, S., Monteiro, F.J., Reinforcement of hydroxyapatite by adding P 2O 5-CaO glasses with Na 2O, K 2O, MgO (1996) J Mater Sci Mater Med, 7, pp. 187-189; 
Lopes, M.A., Knowles, J.C., Kuru, L., Santos, J.D., Monteiro, F.J., Olsen, I., Flow cytometry for assessing biocompatibility (1998) J Biomed Mater Res, 41, pp. 649-656; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Ohtsuki, C., Osaka, A., Kaneko, S., Inoue, H., Osteocompatibility and in vivo evaluation of glass reinforced hydroxyapatite composites (1999) Bioceramics, 12 vol., pp. 421-424. , Ohgushi H., Hastings G.W., Yoshikawa T. (Eds.), Japan: World Scientific; 
Santos, J.D., Vasconcelos, M., Reis, R.L., Afonso, A., Monteiro, F.J., Hastings, G.W., Glass reinforced hydroxyapatite composites; physical properties and preliminary histological studies in rabbits (1994) Bioceramics, 7 vol., pp. 243-248. , Andersson O.H., Yli-Urpo A. (Eds.), Finland: Pergamon Press; 
Klein, C.P.A.T., Wolke, J.G.C., de Blieck-Hogervorst, J.M.A., de Groot, K., Features of calcium phosphate plasma-sprayed coatings; an in vitro study (1994) J Biomed Mater Res, 28, pp. 961-967; 
Klein, C.P.A.T., Wolke, J.G.C., de Blieck-Hogervorst, J.M.A., de Groot, K., Calcium phosphate plasma-sprayed coatings and their stability; an in vivo study (1994) J Biomed Mater Res, 28, pp. 909-917; 
Langnbucher, F., Benz, D., K{\"u}rth, W., M{\"o}ller, H., Otz, M., Standardized Flow-cell method as an alternative to existing pharmacopoeial dissolution testing (1989) Pharm Ind, 51, pp. 1276-1281; 
Santos, J.D., Knowles, J.C., Reis, R.L., Monteiro, F.J., Hastings, G.W., Microstructural characterization of glass-reinforced hydroxyapatite composites (1994) Biomaterials, 15, pp. 5-10; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Knowles, J.C., Glass-reinforced hydroxyapatite; a comprehensive study of the effect of glass composition on crystallography of the composite (1998) J Biomed Mater Res, 39, pp. 244-251; 
Thomas M. Ultraviolet and visible spectroscopy, second edition. In: Ando DJ, editor. England: Wiley, 1996. p. 16-30Itokazu, M., Itoh, Y., Fukuta, M., Miyamato, K., Ohara, A., Oshima, K., Nishimoto, Y., Shimizu, K., Treatment of osteomyelitis by using antibiotic loaded porous ceramic (1999) Bioceramics, 12 vol., pp. 3-6. , Ohgushi H., Hastings G.W., Yoshikawa T. (Eds.), Japan: World Scientific; 
Shinto, Y., Uchida, A., Korkusuz, F., Araki, N., Ono, K., Calcium hydroxyapatite ceramic used as a delivery system for antibiotics (1992) J Bone Jt Surg, 74 B, pp. 600-604; 
Downes, S., Clifford, C.J., Scotchford, C., Klein, C.P.A.T., Comparison of the release of growth hormone from hydroxyapatite, heat-treated hydroxyapatite, and fluoroapatite coatings on titanium (1995) J Biomed Mater Res, 29, pp. 1053-1060; 
Curtis, M.A., Griffiths, G.S., Johnson, N.W., The total protein concentration of gingival crevicular fluid. Variation with sampling time and gingival inflammation (1988) J Clin Periondontol, 15, pp. 628-632; 
Stoltze K. Concentration of metronidazole in periodontal pockets after application of a metronidazole 25\% dental gel. J Clin Periondontol 1992, 689-701Jones, A.A., Koenman, K.S., Newbold, D.A., Manwell, M.A., Clinical and microbiological effects of controlled release locally delivered minocycline in periodontitis (1994) J Periodontol, 65, pp. 1058-1066
},
	month = {2001///},
	pages = {1393 - 1400},
	abstract = {As a potential therapy for periodontitis, sodium ampicillin, a broad spectrum antibiotic, was adsorbed onto hydroxyapatite (HA) and glass-reinforced hydroxyaptite (GR-HA) composites, and was subsequently released in vitro. The sodium ampicillin, was adsorbed more on HA compared to the GR-HA composites. X-ray diffraction (XRD) and Rietveld analysis were used to identify and quantify the levels of HA and β-tricalcium phosphate (β-TCP) in the microstructure of the GR-HA composites. Lattice parameters changes were observed for the β-TCP phase dependant on the amount of glass added. The release kinetics were shown to be divided into three stages, the first of which where a large amount of sodium ampicillin is released, followed by a slower release rate and then a final stage where the release amount approaches zero, until no more sodium ampicillin was present. X-ray photoeletron spectroscopy (XPS) studies were carried out in order to ensure that the entire antibiotic adsorbed onto the materials had been released. These kinetics studies have indicated the possibility of using these materials as possible carriers for drug delivery. Copyright {\textcopyright} 2001 Elsevier Science Ltd.},
	keywords = {Adsorption, ampicillin, Antibiotics, article, calcium phosphate, composite material, controlled study, drug adsorption, Drug delivery, drug delivery system, Drug release, Durapatite, glass, Glass-reinforced hydroxyapatite, hydroxyapatite, Kinetics, Microstructure, Penicillins, periodontitis, priority journal, Reinforcement, Rietveld analysis, roentgen spectroscopy, Sodium ampicillin, Sodium compounds, structure analysis, unclassified drug, X ray diffraction, X ray diffraction analysis, X ray photoelectron spectroscopy, X-Ray Diffraction},
	isbn = {01429612 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0035372020\&partnerID=40\&md5=72e1b530ae04faed9cceb376c0246aa8},
	author = {Queiroz, A.C. and Santos, J.D. and Monteiro, F.J. and Gibson, I.R. and Knowles, J.C.}
}
