



@article {2568,
	title = {Histological effects of iron accumulation on mice liver and spleen after administration of a metallic solution},
	journal = {BiomaterialsBiomaterials},
	volume = {20},
	year = {1999},
	note = {Cited By (since 1996): 15Export Date: 21 November 2012Source: ScopusCODEN: BIMADdoi: 10.1016/S0142-9612(99)00124-6PubMed ID: 10555088Language of Original Document: EnglishCorrespondence Address: Pereira, M.C.; Departamento de Engenharia Quimica, Faculdade de Engenharia, Universidade do Porto, Rua dos Bragas, 4050-123 Porto, Portugal; email: mcsp@fe.up.ptChemicals/CAS: Iron, 7439-89-6; SolutionsReferences: Rheinold, J.B., Trace elements - A selective survey (1975) Clin Chem, 21, p. 476;Crichton, R.R., Ward, R.J., Structure and molecular biology of iron binding-proteins and the regulation of free iron pools (1992) Iron and Human Diseases, pp. 23-75. , R.B. Lauffer. Boca Raton: CRC Press Inc; 
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Winter, G.D., Tissue reactions to metallic wear and corrosion products in human patients (1974) J Biomed Mater Res Symp, 5, pp. 11-26; 
Winter, G.D., Wear and corrosion products in tissues and the reactions they provoke (1976) Biocompatibility of Implant Materials, pp. 28-54. , In: Williams, DF, editor London; 
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Pohler, O.E.M., Degradation of metallic orthopedic implants (1983) Biomaterials in Reconstructive Surgery, pp. 196-197. , In: Rubin LR, editor London: The C.V. Mosby Company; 
Lux, F., Zeisler, R., Investigations of the corrosive deposition of components of metal implants and the behaviour of biological trace elements in metallosis tissue by means of instrumental multi-element activation analysis (1974) J Radioanal Chem, 19, pp. 289-297; 
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Pereira, M.L., Pereira, M.C., Sousa, J.P., Evaluation of nickel effects on mouse liver: Tissue response and metal ion accumulation (1995) Biomed Lett, 52, pp. 235-244; 
Pereira, M.C., Pereira, M.L., Sousa, J.P., Evaluation of nickel toxicity on liver, spleen and kidney of mice after administration of high-dose metal ion (1998) J Biomed Mater Res, 40, pp. 40-47; 
Pereira, M.C., Sousa, J.P., Nickel quantification in mice organs by adsorptive cathodic stripping voltammetry using microelectrodes (1997) Electroanalysis, 9, pp. 150-154; 
Pereira, M.C., Pereira, M.L., Sousa, J.P., Adsorptive stripping measurements of iron accumulation in mice kidney using microelectrodes and histological features (1998) J Trace Elements Med Biol, 12, pp. 50-55; 
Van Den Berg, C.M.G., Huang, Z.Q., Determination of iron in seawater using cathodic stripping voltammetry proceeded by adsorptive collection with the hanging mercury drop electrode (1984) J Electroanal Chem, 177, pp. 269-280; 
Smith, G.K., Black, J., Estimation of in vivo type 316L stainless steel corrosion rate from blood transport and organ accumulation data (1985) Corrosion and Degradation of Implant Materials: Second Symposium, pp. 223-247. , A.C. Fraker, \& C.D. Griffin. Philadelphia: American Society for Testing and Materials; 
Barbosa, M.A., (1991) Biomaterials Degradation, p. 227. , Barbosa M.A. The Netherlands: Elsevier Science Publisher; 
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Britton, S.R., Ramm, G.A., Olynyk, J., Singh, R., O{\textquoteright}Neill, R., Bacon, B.R., Pathophysiology of iron toxicity (1994) Progress in Iron Research, pp. 239-253. , C. et al. Hershko. New York: Plenum Press
},
	month = {1999///},
	pages = {2193 - 2198},
	publisher = {Elsevier Science Ltd},
	abstract = {Special attention has been focused on the toxicity of some metallic species released from implanted materials, which accumulate in vital organs over long periods of time. A set of experiments with mice was designed to investigate the individual effects caused by iron in the liver and spleen. Histological features of these organs were evaluated and slight morphological changes were observed during the treatment time suggesting a negative correlation with the duration of the iron treatment. In addition, to associate the histological changes in the organs with iron accumulation an electrochemical method, adsorptive stripping voltammetry, was chosen to quantify the iron levels in these mentioned organs. The accuracy of the proposed method was checked by atomic absorption spectrometry. Both organs showed elevated concentrations of iron, nearly twofold, 7 days after iron administration compared to control organs.Special attention has been focused on the toxicity of some metallic species released from implanted materials, which accumulate in vital organs over long periods of time. A set of experiments with mice was designed to investigate the individual effects caused by iron in the liver and spleen. Histological features of these organs were evaluated and slight morphological changes were observed during the treatment time suggesting a negative correlation with the duration of the iron treatment. In addition, to associate the histological changes in the organs with iron accumulation an electrochemical method, adsorptive stripping voltammetry, was chosen to quantify the iron levels in these mentioned organs. The accuracy of the proposed method was checked by atomic absorption spectrometry. Both organs showed elevated concentrations of iron, nearly twofold, 7 days after iron administration compared to control organs.
},
	keywords = {Absorption spectroscopy, accuracy, Adsorption, Adsorptive stripping voltametry, Adsorptive stripping voltammetry, animal experiment, animal model, animal tissue, Animalia, Animals, article, atomic absorption spectrometry, Atomic spectroscopy, bioaccumulation, biomaterial, controlled study, Corrosion, electrochemistry, histology, histopathology, Implants (surgical), Injections, Subcutaneous, Iron, iron metabolism, Kinetics, Liver, liver toxicity, male, metal implantation, Mice, morphology, mouse, nonhuman, Organ Size, potentiometry, priority journal, quantitative assay, Solutions, Spleen, Stainless steel, tissue distribution, toxicity},
	isbn = {01429612 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0032855084\&partnerID=40\&md5=2e7274d8d0372ff55881c2d9de94c54b},
	author = {Pereira, M.C. and Pereira, M.L. and Sousa, J.P.}
}
