



@article {2587,
	title = {Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion},
	journal = {Journal of Biomedical Materials ResearchJ. Biomed. Mater. Res.},
	volume = {40},
	year = {1998},
	note = {Cited By (since 1996): 27Export Date: 21 November 2012Source: ScopusCODEN: JBMRBdoi: 10.1002/(SICI)1097-4636(199804)40:1<40::AID-JBM5>3.0.CO;2-RPubMed ID: 9511097Language of Original Document: EnglishCorrespondence Address: Sousa, J.P.; Instituto de Engenharia Biomedica, Faculdade de Engenharia, Universidade do Porto, Praca Coronel Pacheco, 1, 4050 Porto, PortugalChemicals/CAS: Nickel, 7440-02-0References: Cigada, A., Rondelli, G., Vicentini, B., Brunella, F., Dallaspezia, G., Corrosion behavior of high nitrogen stainless steels for biomedical applications (1994) Compatibility of Biomedical Implants, pp. 185-195. , P. Kovacs and N. S. Istephanous (eds.), The Electrochemical Society, Inc., Pennington, New Jersey;Bumgardner, J.D., Lucas, L.C., An evaluation of the corrosion properties and cellular compatibility of nickel-based dental casting alloys (1994) Compatibility of Biomedical Implants, pp. 241-252. , P. Kovacs and N. S. Istephanous (eds.), The Electrochemical Society, Inc., Pennington, New Jersey; 
Williams, D.F., (1990) Encyclopedia of Medical and Dental Materials, , Pergamon Press, Oxford; 
Muller, A.W.J., Maessen, F.J.M.J., Davidson, C.L., Determination of the corrosion rates of six dental NiCrMo alloys in an artificial saliva by chemical analysis of the medium using ICP-AES (1990) Dent. Mater., 6, pp. 63-68; 
Bumgardner, J.D., Lucas, L.C., Surface analysis of nickel-chromium dental alloys (1993) Dent. Mater., 9, pp. 252-259; 
Williams, D.F., (1981) Systemic Aspects of Biocompatibility, 1-2. , CRC Press, Boca Raton, Florida; 
Tracana, R.B., Pereira, M.L., Abreu, A.M., Sousa, J.P., Carvalho, G.S., Stainless steel products cause alterations on mouse spleen cellular populations (1995) J. Mater. Sci. Mater. Med., 6, pp. 56-61; 
Tracana, R.B., Sousa, J.P., Carvalho, G.S., Mouse inflammatory response to stainless steel corrosion products (1994) J. Mater. Sci. Mater. Med., 5, pp. 596-600; 
Jacks, J.J., Skiper, A.K., Black, J., Urban, R.M., Galante, J.O., Release and excretion of metal in patients who have a total hip replacement component made of titanium base alloy (1991) J. Bone Joint Surg., 73 A, pp. 1475-1486; 
Stulberg, B.N., Merrit, K., Bawer, T.W., Metallic wear debris in metal backed patellar failure (1994) J. Appl. Biomater., 5, pp. 9-16; 
Panigutti, M.A., Merrit, K., Bruner, R.J., Kraay, M.J., Brown, S.A., Correlation of allergy, metal levels, implant alloy, and implant damage in patients undergoing revision joint arthroplastics (1992) Trans. Soc. Biomater., 15, p. 7; 
Abreu, A.M., Tracana, R.B., Carvalho, G.S., Sousa, J.P., Determination of metal ions released from metallic biomaterials using absorption spectroscopy and microelectrodes (1995) Biomed. Lett., 52, pp. 133-148; 
(1986) Health Assessment Document for Nickel and Nickel Compounds, , EPA/600/8-83/012FF, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; 
Black, J., (1988) Orthopedic Biomaterials in Research and Practice, , Churchill Livingstone, New York; 
Nieboer, E., Rossetto, F.E., Menon, C.R., Toxicology of nickel compounds (1980) Nickel Toxicology, pp. 359-401. , S. S. Brown and F. W. Sunderman, Jr. (eds.), Academic Press, Inc., New York; 
Pereira, M.L., Pereira, M.C., Sousa, J.P., Evaluation of nickel effects on mouse liver: Tissue response and metal ion accumulation (1995) Biomed. Lett., 52, pp. 235-244; 
Pereira, M.C., Faria, J.L., Reis, M.L., Sousa, J.P., Nickel quantification in mice organs by adsorptive stripping voltammetry using mercury microelectrodes (1996) Electroanalysis, 9, pp. 1-5; 
Black, J., Systemic distribution and excretion (1981) Biomedical Engineering and Instrumentation, p. 180. , R. Plonsey and J. L. Katz (eds.), Marcel Dekker, Inc., New York; 
Pohler, O.E.M., Degradation of metallic orthopedic implants (1983) Biomaterials in Reconstructive Surgery, p. 197. , L. R. Rugin (ed.), The C. V. Mosby Company, St. Louis; 
Ross, M.H., Romrell, L.J., (1989) Histology - A Text and Atlas, , Williams and Wilkins, New York
},
	month = {1998///},
	pages = {40 - 47},
	publisher = {John Wiley \& Sons Inc},
	abstract = {The toxic effects caused by nickel (Ni) per si were explored by performing in vivo studies on mice following subcutaneous administration of a metallic solution of nickel at 1, 2, 3, and 4 weeks to evaluate the side effects of this metal ion when released from stainless steel implants. Other groups were similarly injected with HBSS and used as controls. Accumulation of Ni ions on liver, spleen, and kidney was assessed by an electrochemical method, adsorptive stripping voltammetry (AdSV) using microelectrodes, and atomic absorption spectrometry (AAS). Alterations of those organs induced by Ni ions were studied, showing that several histological changes had been induced. Chemical analysis and histological features indicate that Ni is partially accumulated in the study organs.The toxic effects caused by nickel (Ni) per si were explored by performing in vivo studies on mice following subcutaneous administration of a metallic solution of nickel at 1, 2, 3, and 4 weeks to evaluate the side effects of this metal ion when released from stainless steel implants. Other groups were similarly injected with HBSS and used as controls. Accumulation of Ni ions on liver, spleen, and kidney was assessed by an electrochemical method, adsorptive stripping voltammetry (AdSV) using microelectrodes, and atomic absorption spectrometry (AAS). Alterations of those organs induced by Ni ions were studied, showing that several histological changes had been induced. Chemical analysis and histological features indicate that Ni is partially accumulated in the study organs.
},
	keywords = {Absorption spectroscopy, Adsorptive stripping voltammetry, animal experiment, animal tissue, Animals, article, atomic absorption spectrometry, biomaterial, body weight, controlled study, Dose-Response Relationship, Drug, electrochemistry, Evaluation Studies, histology, Implants (surgical), Kidney, Liver, liver toxicity, Living systems studies, Mice, Microelectrodes, mouse, nephrotoxicity, Nickel, nonhuman, potentiometry, Spectrophotometry, Atomic, Spleen, spleen injury, Stainless steel, toxicity},
	isbn = {00219304 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0032053959\&partnerID=40\&md5=b1b91f83e841302830f88702c7146ae0},
	author = {Pereira, M.C. and Pereira, M.L. and Sousa, J.P.}
}
