



@article {3315,
	title = {Role of sparc in bone remodeling and cancer-related bone metastasis},
	journal = {Journal of Cellular Biochemistry},
	volume = {115},
	year = {2014},
	note = {Export Date: 21 November 2014},
	month = {2014},
	pages = {17 - 26},
	abstract = {There is a growing socioeconomic recognition that clinical bone diseases such as bone infections, bone tumors and osteoporotic bone loss mainly associated with ageing, are major issues in today{\textquoteright}s society. SPARC (secreted protein, acidic and rich in cysteine), a matricellular glycoprotein, may be a promising therapeutic target for preventing or treating bone-related diseases. In fact, SPARC is associated with tissue remodeling, repair, development, cell turnover, bone mineralization and may also participate in growth and progression of tumors, namely cancer-related bone metastasis. Yet, the function of SPARC in such biological processes is poorly understood and controversial. The main objective of this work is to review the current knowledge related to the activity of SPARC in bone remodeling, tumorigenesis, and bone metastasis. Progress in understanding SPARC biology may provide novel strategies for bone regeneration and the development of anti-angiogenic, anti-proliferative, or counter-adhesive treatments specifically against bone metastasis. {\textcopyright} 2013 Wiley Periodicals, Inc. {\textcopyright} 2013 Wiley Periodicals, Inc.},
	keywords = {BONE METASTASIS, bone remodeling, SPARC, TUMORIGENESIS},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84887856025\&partnerID=40\&md5=bcb4dc43db0bb9be75051f4493c74d3d},
	author = {Ribeiro, N. and Sousa, S.R. and Brekken, R.A. and Monteiro, F.J.}
}
@article {2248,
	title = {Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion and morphology},
	journal = {Journal of Colloid and Interface ScienceJ. Colloid Interface Sci.},
	volume = {351},
	year = {2010},
	note = {Cited By (since 1996): 12Export Date: 21 November 2012Source: ScopusCODEN: JCISAdoi: 10.1016/j.jcis.2010.08.013PubMed ID: 20810127Language of Original Document: EnglishCorrespondence Address: Ribeiro, N.; INEB - Instituto de Engenharia Biom{\'e}dica, Divis{\~a}o de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal; email: nribeiro@ineb.up.ptChemicals/CAS: fibronectin, 86088-83-7; hydroxyapatite, 1306-06-5, 51198-94-8; osteonectin, 104052-78-0; protein, 67254-75-5; Ceramics; Durapatite, 1306-06-5; Fibronectins; OsteonectinReferences: Griffith, L.G., Naughton, G., (2002) Science, 295, p. 1009;Webster, T.J., Ergun, C., Doremus, R.H., Siegel, R.W., Bizios, R., (2000) J. Biomed. Mater. Res., 51, pp. 475-483; 
Webster, T.J., Siegel, R.W., Bizios, R., (1999) Biomaterials, 20, pp. 1221-1227; 
Jun, I.K., Jang, J.H., Kim, H.W., Kim, H.E., (2005) J. Mater. Sci., 40, pp. 2891-2895; 
Geiger, B., Bershadsky, A., Pankov, R., Yamada, K.M., (2001) Nat. Rev. Mol. Cell Biol., 2, pp. 793-805; 
Globus, R.K., Doty, S.B., Lull, J.C., Holmuhamedov, E., Humphries, M.J., Damsky, C.H., (1998) J. Cell Sci., 111, pp. 1385-1393; 
Moursi, A.M., Damsky, C.H., Lull, J., Zimmerman, D., Doty, S.B., Aota, S.I., Globus, R.K., (1996) J. Cell Sci., 109, pp. 1369-1380; 
Garcia, A.J., Vega, M.D., Boettiger, D., (1999) Mol. Biol. Cell, 10, pp. 785-798; 
Petrie, T.A., Capadona, J.R., Reyes, C.D., Garcia, A.J., (2006) Biomaterials, 27, pp. 5459-5470; 
Dolatshahi-Pirouz, A., Jensen, T., Foss, M., Chevallier, J., Besenbacher, F., (2009) Langmuir, 25, pp. 2971-2978; 
Shen, J.-W., Wu, T., Wang, Q., Pan, H.-H., (2008) Biomaterials, 29, pp. 513-532; 
Brekken, R.A., Sage, E.H., (2000) Matrix Biol., 19, pp. 569-580; 
Termine, J.D., Kleinman, H.K., Whitson, S.W., Conn, K.M., McGarvey, M.L., Martin, G.R., (1981) Cell, 26, pp. 99-105; 
Liao, S., Ngiam, M., Chan, C.K., Ramakrishna, S., (2009) Biomed. Mater., 4; 
Sarvestani, A.S., He, X., Jabbari, E., (2008) Eur. Biophys. J. Biophys. Lett., 37, pp. 229-234; 
Majeska, R.J., Cell Biology of Bone (1934), pp. 2-3. , in: S.C. Cowin (Ed.), Bone Mechanics HandbookKoblinski, J.E., Wu, M., Demeler, B., Jacob, K., Kleinman, H.K., (2005) J. Cell Sci., 118, pp. 2965-2974; 
O{\textquoteright}Brien, J., Wilson, I., Orton, T., Pognan, F., (2000) Eur. J. Biochem., 267, pp. 5421-5426; 
Ribeiro, C.C., Gibson, I., Barbosa, M.A., (2006) Biomaterials, 27, pp. 1749-1761; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., Serro, A.P., Saramago, B., (1999) J. Biomed. Mater. Res., 45, pp. 370-375; 
Suzuki, T., Nishizawa, K., Yokogawa, Y., Nagata, F., Kawamoto, Y., Kameyama, T., (1996) J. Ferment. Bioeng., 81, pp. 226-232; 
Suzuki, T., Yamamoto, T., Toriyama, M., Nishizawa, K., Yokogawa, Y., Mucalo, M.R., Kawamoto, Y., Kameyama, T., (1997) J. Biomed. Mater. Res., 34, pp. 507-517; 
Holland, N.B., Marchant, R.E., (2000) J. Biomed. Mater. Res., 51, pp. 307-315; 
Kothapalli, C., Wei, M., Vasiliev, A., Shaw, M.T., (2004) Acta Mater., 52, pp. 5655-5663; 
Sousa, S.R., Manuela Bras, M., Moradas-Ferreira, P., Barbosa, M.A., (2007) Langmuir, 23, pp. 7046-7054; 
Rouahi, M., Champion, E., Gallet, O., Jada, A., Anselme, K., (2006) Colloids Surf., B - Biointerfaces, 47, pp. 10-19; 
dos Santos, E.A., Farina, M., Soares, G.A., Anselme, K., (2008) J. Mater. Sci. - Mater. Med., 19, pp. 2307-2316; 
Amaral, I.F., Unger, R.E., Fuchs, S., Mendonca, A.M., Sousa, S.R., Barbosa, M.A., Pego, A.P., Kirkpatrick, C.J., (2009) Biomaterials, 30, pp. 5465-5475; 
Sousa, S.R., Moradas-Ferreira, P., Barbosa, M.A., (2005), pp. 1173-1178. , TiO2 type influences fibronectin adsorption, in: 19th Conference of the European-Society-for-Biomaterials, Springer, Sorrento, ItalyGoldstein, A.S., DiMilla, P.A., (2002) J. Biomed. Mater. Res., 59, pp. 665-675; 
Michael, K.E., Vernekar, V.N., Keselowsky, B.G., Meredith, J.C., Latour, R.A., Garcia, A.J., (2003) Langmuir, 19, pp. 8033-8040; 
Anselme, K., Bigerelle, M., (2005) Acta Biomater., 1, pp. 211-222; 
Anselme, K., Bigerelle, M., Noel, B., Dufresne, E., Judas, D., Iost, A., Hardouin, P., (2000) J. Biomed. Mater. Res., 49, pp. 155-166; 
Wang, C., Duan, Y., Markovic, B., Barbara, J., Rolfe Howlett, C., Zhang, X., Zreiqat, H., (2004) Biomaterials, 25, pp. 2949-2956; 
Smith, I.O., McCabe, L.R., Baumann, M.J., (2006) Int. J. Nanomed., 1, pp. 189-194; 
Bernards, M.T., Qin, C.L., Jiang, S.Y., Bone osteopontin, and bovine serum albumin (2008) Colloids Surf., B - Biointerfaces, 64, pp. 236-247; 
Durrieu, M.C., Pallu, S., Guillemot, F., Bareille, R., Amedee, J., Baquey, C., Labrugere, C., Dard, M., (2004) J. Mater. Sci. - Mater. Med., 15, pp. 779-786; 
Itoh, D., Yoneda, S., Kuroda, S., Kondo, H., Umezawa, A., Ohya, K., Ohyama, T., Kasugai, S., (2002) J. Biomed. Mater. Res., 62, pp. 292-298; 
Funk, S.E., Sage, E.H., (1993) J. Cell. Physiol., 154, pp. 53-63; 
Hagan, S., Hiscott, P., Sheridan, C., Wong, D., Grierson, I., McGalliard, J., (2003) Mol. Vis., 9, pp. 87-92; 
Deligianni, D., Korovessis, P., Porte-Derrieu, M.C., Amedee, J., (2005) J. Spinal Disord. Technol., 18, pp. 257-262; 
Nelson, M., Balasundaram, G., Webster, T.J., (2006) Int. J. Nanomed., 1, pp. 339-349
},
	month = {2010///},
	pages = {398 - 406},
	abstract = {The characteristic topographical features (crystallite dimensions, surface morphology and roughness) of bioceramics may influence the adsorption of proteins relevant to bone regeneration. This work aims at analyzing the influence of two distinct nanophased hydroxyapatite (HA) ceramics, HA725 and HA1000 on fibronectin (FN) and osteonectin (ON) adsorption and MC3T3-E1 osteoblast adhesion and morphology. Both substrates were obtained using the same hydroxyapatite nanocrystals aggregates and applying the sintering temperatures of 725{\textdegree}C and 1000{\textdegree}C, respectively. The two proteins used in this work, FN as an adhesive glycoprotein and ON as a counter-adhesive protein, are known to be involved in the early stages of osteogenesis (cell adhesion, mobility and proliferation). The properties of the nanoHA substrates had an important role in the adsorption behavior of the two studied proteins and clearly affected the MC3T3-E1 morphology, distribution and metabolic activity. HA1000 surfaces presenting slightly larger grain size, higher root-mean-square roughness (Rq), lower surface area and porosity, allowed for higher amounts of both proteins adsorbed. These substrates also revealed increased number of exposed FN cell-binding domains as well as higher affinity for osteonectin. Regarding the osteoblast adhesion results, improved viability and cell number were found for HA1000 surfaces as compared to HA725 ones, independently of the presence or type of adsorbed protein. Therefore the osteoblast adhesion and metabolic activity seemed to be more sensitive to surfaces morphology and roughness than to the type of adsorbed proteins. {\textcopyright} 2010 Elsevier Inc.},
	keywords = {Adhesion, Adhesive proteins, Adsorption, Adsorption behavior, Animals, Apatite, article, Bioceramics, Biological materials, Biomaterials, bone development, Bone Regeneration, cell adhesion, Cell Count, cell metabolism, cell motility, Cell number, cell proliferation, cell strain 3T3, cell structure, Cell-binding domain, Cells, Cultured, cellular distribution, ceramics, controlled study, Crystallite dimension, Crystallite size, Crystallization, Durapatite, Fibronectin, Fibronectin adsorption, Fibronectins, glycoprotein, grain, Grain size, human, human cell, hydroxyapatite, Hydroxyapatite nanocrystals, MC3T3-E1, Metabolic activity, metabolism, Mice, morphology, Nano-HA, nanocrystal, nanoparticles, Nanophased hydroxyapatite, osteoblast, Osteoblast adhesion, Osteoblast morphology, Osteoblasts, Osteogenesis, osteonectin, Osteonectin adsorption, Particle Size, porosity, priority journal, protein, Proteins, Root mean square roughness, Sintering, Sintering temperatures, Surface area, Surface Properties, surface property, Surface roughness, temperature, Topographical features},
	isbn = {00219797 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-77957328472\&partnerID=40\&md5=c4a13ccec89e04dbfe1920fd42fec3f5},
	author = {Ribeiro, N. and Sousa, S.R. and Monteiro, F.J.}
}
