



@article {2351,
	title = {Surface characterization and cell response of a PLA/CaP glass biodegradable composite material},
	journal = {Journal of Biomedical Materials Research - Part AJ. Biomed. Mater. Res. Part A},
	volume = {85},
	year = {2008},
	note = {Cited By (since 1996): 5Export Date: 21 November 2012Source: ScopusCODEN: JBMRCdoi: 10.1002/jbm.a.31546PubMed ID: 17729262Language of Original Document: EnglishCorrespondence Address: Ginebra, M. P.; Department of Materials Science, Institute of Bioengineering of Catalonia (IBEC), Technical University of Catalonia, Avda Diagonal 647, 08028-Barcelona, Spain; email: maria.pau.ginebra@upc.eduChemicals/CAS: 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide, 298-93-1; calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; osteocalcin, 136461-80-8; polylactic acid, 26100-51-6; Alkaline Phosphatase, EC 3.1.3.1; Bone Substitutes; calcium phosphate, 10103-46-5; Calcium Phosphates; Lactic Acid, 50-21-5; Osteocalcin, 104982-03-8; poly(lactic acid), 26100-51-6; PolymersReferences: Barrows, T., Degradable implants materials: A review of synthetic absorbable polymers and their applications (1986) Clin Mater, 1, pp. 233-267;Ciccone, W., Motz, C., Bentley, C., Tasto, J., Bioabsorbable implants in orthopaedics: New developments and clinical applications (2001) J Am Acad Orthop Surg, 9, pp. 280-288; 
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Navarro, M., Ginebra, M.P., Planell, J.A., Barrias, C.C., Barbosa, M., In vitro degradation behavior of a novel bioabsorbable composite material based on PLA and a soluble CaP glass (2005) Acta Biomaterialia, 1, pp. 411-419; 
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},
	month = {2008///},
	pages = {477 - 486},
	abstract = {Bioabsorbable materials are of great interest for bone regeneration applications, since they are able to degrade gradually as new tissue is formed. In this work, a fully biodegradable composite material containing polylactic acid (PLA) and calcium phosphate (CaP) soluble glass particles has been characterized in terms of surface properties and cell response. Cell cultures were performed in direct contact with the materials and also with their extracts, and were evaluated using the MTT assay, alkaline phosphatase activity, and osteocalcin measurements. The CaP glass and PLA were used as reference materials. No significant differences were observed in cell proliferation with the extracts containing the degradation by-products of the three materials studied. A relation between the materials wettability and the material-cell interactions at the initial stages of contact was observed. The most hydrophilic material (CaP glass) presented the highest cell adhesion values as well as an earlier differentiation, followed by the PLA/glass material. The incorporation of glass particles into the PLA matrix increased surface roughness. SEM images showed that the heterogeneity of the composite material induced morphological changes in the cells cytoskeleton. {\textcopyright} 2007 Wiley Periodicals, Inc.},
	keywords = {3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide, Absorbable Implants, alkaline phosphatase, article, Biodegradable composite materials, biodegradable implant, Biodegradation, Bone, Bone Regeneration, Bone Substitutes, calcium phosphate, Calcium phosphates, cell adhesion, Cell culture, cell function, cell interaction, Cell Line, cell proliferation, Cell response, Composite materials, cytoskeleton, glass, human, human cell, Humans, hydrophilicity, hydrophobicity, In vitro test, Lactic Acid, materials testing, Osteoblasts, osteocalcin, polylactic acid, Polymers, scanning electron microscope, Surface analysis, Surface Properties, wettability},
	isbn = {15493296 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-42149187233\&partnerID=40\&md5=8942b2e00b94ff0f723261e1893d04b5},
	author = {Navarro, M. and Engel, E. and Planell, J.A. and Amaral, I. and Barbosa, M. and Ginebra, M.P.}
}
@article {2450,
	title = {In vitro degradation behavior of a novel bioresorbable composite material based on PLA and a soluble CaP glass},
	journal = {Acta BiomaterialiaActa Biomater.},
	volume = {1},
	year = {2005},
	note = {Cited By (since 1996): 24Export Date: 21 November 2012Source: Scopusdoi: 10.1016/j.actbio.2005.03.004PubMed ID: 16701822Language of Original Document: EnglishCorrespondence Address: Ginebra, M.P.; Reference Centre for Bioengineering of Catalonia (CREBEC), Department of Materials Science, Universitat Polit{\`e}cnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, Spain; email: maria.pau.ginebra@upc.esChemicals/CAS: calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; polylactic acid, 26100-51-6; Bone Substitutes; calcium phosphate, 10103-46-5; Calcium Phosphates; Lactic Acid, 50-21-5; poly(lactic acid), 26100-51-6; PolymersManufacturers: Purac, NetherlandsReferences: Rokkanen, P., Bioabsorbable fixation in orthopaedic surgery and traumatology (2000) Biomaterials, 21, pp. 2607-2613;Middleton, J.C., Tipton, A.J., Synthetic biodegradable polymers as orthopedic devices (2000) Biomaterials, 21 (23), pp. 2335-2346; 
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},
	month = {2005///},
	pages = {411 - 419},
	abstract = {Poly(α-hydroxy acids), and in particular polylactic acid (PLA), are nowadays amongst the most used bioabsorbable materials. However, this polymer may not meet some application requirements due to inadequate mechanical properties and or its degradation characteristics. A possible strategy to tackle this problem is the incorporation of an inorganic phase into the polymeric matrix. In this work a new fully biodegradable composite material made with PLA and calcium phosphate soluble glass particles has been developed. The behaviour of the PLA/ glass composite has been analysed during its degradation in simulated physiological conditions by means of weight loss, molecular weight and thermal properties analysis and electron microscopy observation. The results showed that the incorporation of phosphate glass particles into the polymer significantly accelerated the degradation of the PLA and induced the formation of calcium phosphate precipitates at the composite surface. {\textcopyright} 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.},
	keywords = {Absorbable Implants, Absorption, article, biodegradability, Biodegradable composite, Biomimetic materials, Body fluids, Bone Regeneration, Bone Substitutes, calcium phosphate, Calcium phosphates, composite material, Degradation, electron microscopy, glass, In vitro degradation, in vitro study, Lactic Acid, materials testing, molecular weight, observation, Phosphate glass, polylactic acid, Polymers, precipitation, priority journal, reaction analysis, simulation, Solubility, Surface Properties, surface property, temperature, weight reduction},
	isbn = {17427061 (ISSN)},
	author = {Navarro, M. and Ginebra, M.P. and Planell, J.A. and Barrias, C.C. and Barbosa, M.A.}
}
