



@article {2364,
	title = {A clinical report of bone regeneration in maxillofacial surgery using bonelike{\textregistered} synthetic bone graft},
	journal = {Journal of Biomaterials ApplicationsJ. Biomater. Appl.},
	volume = {22},
	year = {2008},
	note = {Cited By (since 1996): 6Export Date: 21 November 2012Source: ScopusCODEN: JBAPEdoi: 10.1177/0885328207078260Language of Original Document: EnglishCorrespondence Address: Santos, J.D.; Instituto de Engenharia Biom{\'e}dica, Laborat{\'o}rio de Biomateriais, Rua Campo Alegre 823, 4150-180 Porto, Portugal; email: jdsantos@fe.up.ptChemicals/CAS: Bone SubstitutesReferences: Mohamed, A., Sudha, K., Kim, F., Karl, K., Scott, P.B., Bone Graft Substitutes (2003) Cell Based Approaches for Bone Graft Substitutes, p. 127. , In: Laurencin, C.T. (ed.), Chapter 7 ASTM - International, USA;Mellonig, J.T., Prewett, A.B., Moyer, M.P., HIV Inactivation in a Bone Allograft (1992) J. Periodontol., 63, p. 979; 
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Lopes, M.A., Santos, J.D., Monteiro, F.J., Knowles, J.C., Glass Reinforced Hydroxyapatite: A Comprehensive Study of the Effect of Glass Composition on the Crystallography of the Composite (1998) J. Biomed. Mater. Res., 39, p. 244; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., Glass-reinforced Hydroxyapatite Composites: Fracture Toughness and Hardness Dependence on Microstructural Characteristics (1999) Biomaterials, 20, p. 2085; 
Lopes, M.A., Silva, R.F., Monteiro, F.J., Santos, J.D., Microstructural Dependence of Young{\textquoteright}s and Shear Moduli of P 2 O 2 Glass Reinforced Hydroxyapatite for Biomedical Applications (2000) Biomaterials, 21, p. 749; 
Lopes, M.A., Santos, J.D., Monteiro, F.J., Ohtsuki, C., Osaka, A., Kaneko, S., Inoue, H., Push-out Testing and Histological Evaluation of Glass Reinforced Hydroxyapatite Composites Implanted in the Tibia of Rabbits (2001) J. Biomed. Mater. Res., 54, p. 463; 
Lobato, J.V., Hussain, N.S., Botelho, C.M., Rodrigues, J.M., Lu{\'\i}s, A.L., Maur{\'\i}cio, A.C., Lopes, M.A., Santos, J.D., Assessment of the Potential of Bonelike{\textregistered} Graft for Bone Regeneration by using an Animal Model (2005) Key. Eng. Mater., 877, pp. 284-286; 
Lobato, J.V., Hussain, N.S., Botelho, C.M., Mauricio, A.C., Afonso, A., Ali, N., Santos, J.D., Assessment of Bonelike{\textregistered} Graft with a Resorbable Matrix using an Animal Model (2006) Thin Solid Films, 515, p. 362; 
Duarte, F., Santos, J.D., Afonso, A., Medical Applications of Bonelike{\textregistered} in Maxillofacial Surgery (2004) Mater. Sci. Forum, 370, pp. 455-456; 
Gutierres, M., Hussain, N.S., Afonso, A., Almeida, L., Cabral, T., Lopes, M.A., Santos, J.D., Biological Behaviour of Bonelike{\textregistered} Graft Implanted in Tibia of Humans (2005) Key Eng. Mater., 1041, pp. 284-286; 
LeGeros, R.Z., Properties of Osteoconductive Biomaterials: Calcium Phosphates (2002) Clin. Orthop., 395, p. 81; 
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Hirotsugu, H., Norio, A., Kimimitsu, O., Noritaka, F., Ohnishi, H., Okada, A., Nomura, S., Maeda, T., A Histological Evaluation on Self setting α-tricalcium Phosphate Applied in the Rat Bone Cavity (2004) Biomaterials, 25, p. 431; 
Meinel, L., Betz, O., Fajardo, R., Hofmann, S., Nazarian, A., Cory, E., Hilbe, M., Kirker-Head, C., Silk Based Biomaterials to Heal Critical Sized Femur Defects (2006) Bone, 39, p. 922; 
Lim, S.C., Lee, M.J., Yeo, H.H., Effects of Various Implant Materials on Regeneration of Calvarial Defects in Rats (2000) Pathol. Int., 50, p. 594; 
Carano, R.A.D., Filvaroff, E.H., Angiogenesis and Bone Repair (2003) Drug Discov. Today, 21, p. 980; 
Gutierres, M., Hussain, N.S., Lopes, M.A., Afonso, A., Cabral, A.T., Almeida, L., Santos, J.D., Histomorphometric Measurements Histological and SEM Analyses of bone/ implant Interface: Clinical Trials using Bonelike{\textregistered} Granules (2006) J. Orthop. Res., 24, p. 953
},
	month = {2008///},
	pages = {373 - 385},
	abstract = {The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike{\textregistered} graft in repairing surgical cystic bone defects. Bonelike{\textregistered} is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocols, radiological examinations are performed and Bonelike{\textregistered} /bone retrieved samples have been analyzed histologically using non-decalcified sections obtained perpendicular to bone length axis. Radiographic examination and histological results clearly demonstrate an extensive new bone formation apposed on Bonelike{\textregistered} granules with a significant degree of maturation. These clinical applications in maxillary bone defects indicate perfect bone bonding between new bone formed and Bonelike{\textregistered} granules, along with partial surface biodegradation. This quick and effective osteoconductive response from Bonelike{\textregistered} may reduce the time needed to reconstruct the bone defected area of patients. {\textcopyright} 2008 Sage Publications.},
	keywords = {adult, article, Bioactivity, Bone, bone prosthesis, Bone Regeneration, Bone Substitutes, bone transplantation, Bonelike{\textregistered}, clinical trial, facial bone, Facial Bones, Female, Histological studies, histology, human, Humans, Implants (surgical), instrumentation, male, Maxillofacial surgery, methodology, Middle Aged, oral surgery, Pathology, Radiography, Radiology, Regeneration, Surgery, Surgery, Oral, Synthetic bone graft, treatment outcome},
	isbn = {08853282 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-37249042186\&partnerID=40\&md5=ab2c9e9614d3f4f521445c149cff57ec},
	author = {Sousa, R.C. and Lobato, J.V. and Maur{\'\i}cio, A.C. and Hussain, N.S. and Botelho, C.M. and Lopes, M.A. and Santos, J.D.}
}
@book {2362,
	title = {Hybrid chitosan membranes tested in sheep for guided tissue regeneration},
	series = {Key Engineering MaterialsKey Eng Mat},
	volume = {361-363 II},
	year = {2008},
	note = {Cited By (since 1996): 1Export Date: 21 November 2012Source: ScopusCODEN: KEMAELanguage of Original Document: EnglishCorrespondence Address: Cortez, P.P.; Centro de Estudos de Ci{\^e}ncia Animal (CECA), Instituto de Ci{\^e}ncias e Tecnologias Agr{\'a}rias e Agro-Alimentares (ICETA), Campus Agr{\'a}rio de Vair{\~a}o, Rua P. Armando Quintas, 4485-661, Vair{\~a}o, Portugal; email: pcortez@mail.icav.up.ptReferences: Nasser, N.J., Friedman, A., Friedman, M., Moor, E., Mosheiff, R., (2005) Injury, 36, p. 1460;Chandy, T., Sharma, C.P., (1990) Biomater. Artif. Cells Artif. Organs, 18, p. 1; 
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Shirosaki, Y., Tsuru, K., Hayakawa, S., Osaka, A., Lopes, M.A., Santos, J.D., Fernandes, M.H., (2004) Key Eng. Mat, 254-256, p. 857; 
Shirosaki, Y., Tsuru, K., Hayakawa, S., Osaka, A., Lopes, M.A., Santos, J.D., Fernandes, M.H., (2005) Biomaterials, 26, p. 485; 
Ueno, H., Yamada, H., Tanaka, I., Kaba, N., Matsuura, M., Okumura, M., Kadosawa, T., Fujinaga, T., (1999) Biomaterials, 20, p. 1407
},
	month = {2008///},
	pages = {1265 - 1268},
	abstract = {Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.},
	keywords = {biodegradability, Biodegradable membrane, Biodegradable membranes, chitosan, Chitosan-silicate hybrid, Guided tissue regeneration (GTR), histology, in vivo study, Membranes, Silicates, Tissue culture},
	isbn = {10139826 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-38149018476\&partnerID=40\&md5=9a6734a40aa84667fe014796596e1ef3},
	author = {Cortez, P.P. and Shirosaki, Y. and Botelho, C.M. and Sim{\~o}es, M.J. and Gartner, F. and Da Costa, R.M.G. and Tsuru, K. and Hayakawa, S. and Osaka, A. and Lopes, M.A. and Santos, J.D. and Maur{\'\i}cio, A.C.}
}
@article {2366,
	title = {Jaw avascular osteonecrosis after treatment of multiple myeloma with zoledronate},
	journal = {Journal of Plastic, Reconstructive and Aesthetic SurgeryJ. Plast. Reconstr. Aesthetic Surg.},
	volume = {61},
	year = {2008},
	note = {Cited By (since 1996): 3Export Date: 21 November 2012Source: Scopusdoi: 10.1016/j.bjps.2006.06.016PubMed ID: 18068658Language of Original Document: EnglishCorrespondence Address: Maur{\'\i}cio, A.C.; Centro de Estudos de Ci{\^e}ncia Animal (CECA), Instituto de Ci{\^e}ncias, Tecnologias Agr{\'a}rias e Agro-Alimentares (ICETA), Campus Agrario Vairao, Rua Padre Armando Quintas, 4485-661 Vair{\~a}o, Portugal; email: ana.colette@mail.icav.up.ptChemicals/CAS: amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; cyclophosphamide, 50-18-0; cyclosporin, 79217-60-0; dexamethasone, 50-02-2; erythropoietin, 11096-26-7; thalidomide, 50-35-1; zoledronic acid, 118072-93-8, 131654-46-1, 165800-06-6, 165800-07-7; Bone Density Conservation Agents; Diphosphonates; Imidazoles; zoledronic acid, 118072-93-8References: Mundy, G.R., Bertoline, D.R., Bone destruction and hypercalcemia in plasma cell myeloma (1986) Semin Oncol, 13 (3), pp. 291-299;Belch, A.R., Bergsagel, D.E., Wilson, K., Effect of daily etidronate on the osteolysis of multiple myeloma (1991) J Clin Oncol, 9 (8), pp. 1397-1402; 
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},
	month = {2008///},
	pages = {99 - 106},
	abstract = {Purpose: Multiple myeloma, the second most common haematopoietic cancer, which represents the collection of plasma-cell neoplasms that invariably becomes fatal when self-renewing myeloma cells begin unrestrained proliferation. The major clinical manifestation of multiple myeloma is related to the loss of bone through osteolysis. This can lead to pathologic fractures, spinal cord compression, hypercalcaemia, and pain. It is also a major cause of morbidity and mortality in these patients, who frequently require radiation therapy, surgery and analgesic medications. Bisphosphonates are specific inhibitors of osteoclastic activity, and are currently used to prevent bone complications and to treat malignant hypercalcaemia in patients with multiple myeloma, or bone metastases from breast and prostate cancers. Hence, osteonecrosis of the mandible has been reported in three patients from Centro Hospitalar de Vila Nova de Gaia (CHVNG) with multiple myeloma treated for over 18-48 months with intravenous zoledronate, commonly prescribed for multiple myeloma therapy. Although, this report alerts clinicians about the potential complication of bone necrosis in patients receiving bisphosphonate therapy, many questions remain concerning the underlying pathogenesis of this process. Patients and methods: The medical and dental records of three patients with multiple myeloma, who were treated in CHVNG in the past 4 years, were reviewed. These three patients presented exposed bone and osteonecrosis of the mandible, and shared one common clinical feature: all of them were treated with bisphosphonate zoledronate, administered intravenously for long periods. Sequential orthopantomograms (OPGs) and histological evaluation have been analysed from the biopsies of the non healing dental extraction sites of these patients. Results: After a routine dental extraction, these patients developed avascular osteonecrosis of the mandible and secondary bone infection with Actinomyces israelii (actinomycotic osteomyelitis), with no evidence of metastatic disease evaluated by biopsy. In these three described clinical cases, surgical debridment without flap elevation, intensive antibiotherapy and the suspension of the zoledronate treatment allowed a partial recovery of the patients. The purpose of this clinical report is to point out that patients suffering from multiple myeloma can develop bone osteonecrosis induced by treatment with bisphosphonates. Research to determine the mechanism of this dental phenomenon is needed to fully validate and substantiate the possible link between bisphosphonate treatment of multiple myeloma or other cancer diseases and avascular osteonecrosis of the jaws. Until then, clinicians involved in the care of patients at risk should consider this possible complication. {\textcopyright} 2006 British Association of Plastic, Reconstructive and Aesthetic Surgeons.},
	keywords = {Actinomyces israelii, adult, aged, amoxicillin, antibiotic therapy, article, avascular necrosis, Avascular osteonecrosis, biopsy, Bisphosphonates, Bone Density Conservation Agents, case report, clinical feature, cyclophosphamide, cyclosporin, dexamethasone, Diphosphonates, drug induced disease, drug inhibition, drug withdrawal, erythropoietin, Female, histology, human, Humans, hypercalcemia, Imidazoles, Jaw, jaw avascular osteonecrosis, male, Mandibular Diseases, morbidity, mortality, Multiple myeloma, osteolysis, Osteonecrosis, pain, panoramic radiography, pathologic fracture, priority journal, Radiography, Panoramic, risk assessment, spinal cord compression, thalidomide, tooth extraction, zoledronic acid},
	isbn = {17486815 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-36649035515\&partnerID=40\&md5=3cc23473fdb164be7f8e067bea9e436e},
	author = {Lobato, J.V. and Maur{\'\i}cio, A.C. and Rodrigues, J.M. and Cavaleiro, M.V. and Cortez, P.P. and Xavier, L. and Botelho, C. and Hussain, N.S. and Santos, J.D.}
}
@article {2402,
	title = {Assessment of Bonelike{\textregistered} graft with a resorbable matrix using an animal model},
	journal = {Thin Solid FilmsThin Solid Films},
	volume = {515},
	year = {2006},
	note = {Cited By (since 1996): 5Export Date: 21 November 2012Source: ScopusCODEN: THSFAdoi: 10.1016/j.tsf.2005.12.153Language of Original Document: EnglishCorrespondence Address: Santos, J.D.; INEB-Instituto de Engenharia Biom{\'e}dica, Laborat{\'o}rio de Biomateriais, Rua Campo Alegre, 823, 4150-180 Porto, Portugal; email: jdsantos@fe.up.ptReferences: Hench, L.L., Wilson, J., (1993) An Introduction to Bioceramics, Singapore, , Scientific W. (Ed);Hench, L.L., (1998) Biomaterials, 19, p. 1419; 
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},
	month = {2006///},
	pages = {362 - 367},
	abstract = {Synthetic bone grafts have been developed to provide an alternative to autografts and allografts. Bonelike{\textregistered} is a patented synthetic osteoconductive bone graft that mimics the mineral composition of natural bone. In the present preliminary animal studies a user-friendly version of synthetic bone graft Bonelike{\textregistered} have been developed by using a resorbable matrix, Floseal{\textregistered}, as a vehicle and raloxifene hydrochloride as a therapeutic molecule, that is known to decrease osteoclast activity and therefore enhanced bone formation. From histological and scanning electron microscopy evaluations, the use of Bonelike{\textregistered} associated with Floseal{\textregistered} and raloxifene hydrochloride showed that new bone was rapidly apposed on implanted granules and also that the presence of the matrix and therapeutic molecule does not alter the proven highly osteoconductivity properties of Bonelike{\textregistered}. Therefore, this association may be one step-forward for the clinical applications of Bonelike{\textregistered} scaffolds since it is much more easy-to-handle when compared to granular materials. {\textcopyright} 2006 Elsevier B.V. All rights reserved.},
	keywords = {animal model, Bone, Bonelike{\textregistered}, FloSeal{\textregistered}, Grafting (chemical), Histological analysis, Mathematical models, Raloxifene hydrochloride, Scanning electron microscopy},
	isbn = {00406090 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33750074198\&partnerID=40\&md5=f24aac62995c1d96ae0e344ccd428ea5},
	author = {Lobato, J.V. and Hussain, N.S. and Botelho, C.M. and Maur{\'\i}cio, A.C. and Afonso, A. and Ali, N. and Santos, J.D.}
}
@article {2401,
	title = {Titanium dental implants coated with Bonelike{\textregistered}: Clinical case report},
	journal = {Thin Solid FilmsThin Solid Films},
	volume = {515},
	year = {2006},
	note = {Cited By (since 1996): 4Export Date: 21 November 2012Source: ScopusCODEN: THSFAdoi: 10.1016/j.tsf.2005.12.151Language of Original Document: EnglishCorrespondence Address: Santos, J.D.; INEB-Instituto de Engenharia Biom{\'e}dica, Laborat{\'o}rio de Biomateriais, Rua Campo Alegre, 823, 4150-180 Porto, Portugal; email: jdsantos@fe.up.ptReferences: Murugan, R., Ramakrishna, S., (2005) Compos. Sci. Technol., 65, p. 2385;Boyle, W.J., Simonet, W.S., Lacey, D.L., (2003) Nature, 423, p. 337; 
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},
	month = {2006///},
	pages = {279 - 284},
	abstract = {The aim of the study was to evaluate the direct bone bonding and osteointegration of the commercial pure (cp Ti) implants coated with Bonelike{\textregistered} synthetic bone graft by plasma spraying. The Bonelike{\textregistered} coated implant was placed in the mandible of a 40-year-old patient and it was removed after a healing period of 3 months with a trephine of 6 mm diameter. The structure of the coating and new bone/implant interface of retrieved samples were evaluated using scanning electron microscopy (SEM) and histological analysis using light microscopy. In vivo microstructure observations of Bonelike{\textregistered} coated retrieved implants showed excellent bone remnants on its surface without any tissue and inflammatory signs observed. The reported Bonelike{\textregistered} coated (cp Ti) implants improved primary stability, which may increase the lifetime of the implant. Bonelike{\textregistered} coated dental implants proved to be highly bioactive with extensive new bone formation and strongly bonded to Bonelike{\textregistered} coating. {\textcopyright} 2005 Elsevier B.V. All rights reserved.},
	keywords = {Bone, Bone Regeneration, Bone/implant interface, Bonelike{\textregistered} coatings, Clinical applications, Dental Implants, Dental prostheses, Hip prostheses, Medical applications, Optical microscopy, Plasma spraying},
	isbn = {00406090 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33750227720\&partnerID=40\&md5=868e14c9913670ea7c14afbf49c8959e},
	author = {Lobato, J.V. and Sooraj Hussain, N. and Botelho, C.M. and Maur{\'\i}cio, A.C. and Lobato, J.M. and Lopes, M.A. and Afonso, A. and Ali, N. and Santos, J.D.}
}
@book {2425,
	title = {Assessment of the potential of Bonelike{\textregistered} graft for bone regeneration by using an animal model},
	series = {Key Engineering MaterialsKey Eng Mat},
	volume = {284-286},
	year = {2005},
	note = {Cited By (since 1996): 5Export Date: 21 November 2012Source: ScopusCODEN: KEMAELanguage of Original Document: EnglishCorrespondence Address: Lobato, J.V.; ICBAS-Instituto de Ci{\^e}ncias Biom{\'e}dicas de Abel Salazar, Universidade do Porto, Largo Professor Abel Salazar 2, PT-4099-003 Porto, Portugal; email: jvlobato@netcabo.ptReferences: Santos, J.D., Hastings, G.W., Knowles, J.C., Sintered Hydroxyapatite Compositions and Method for the Preparation Thereof European Patent WO 0068164Lopes, M.A., Santos, J.D., Monteiro, F.J., Push-out Testing and Histological Evaluation of Glass Reinforced Hydroxyapatite Composites Implanted in the Tibia of Rabbits (2001) J.Biomed Mater Res, 54, pp. 463-469;Lopes, M.A., Santos, J.D., Glass Reinforced Hydroxyapatite Composites; Secondary Phases Proportions and Densification Effects on Biaxial Bending Strength (1999) J.Biomed Mater Res, 48, pp. 734-740; 
Lopes, M.A., Monteiro, F.J., Santos, J.D., Glass Reinforced Hydroxyapatite Composites: Fracture Tougfiness and Hardness Dependence on Microstructural Characteristics (1999) Biomaterials, 2, pp. 2085-2090
},
	month = {2005///},
	pages = {877 - 880},
	abstract = {Bonelike{\textregistered} graft that mimics the inorganic composition of bone tissue has been developed and characterized over the last decade. To evaluate the osteoconductivity of Bonelike{\textregistered} two granule size ranges, one ranging from 150-250μm and the other from 250-500μm were implanted in the femurs of New Zealand White rabbits, aiming at being clinically used in different medical applications, such as dentistry and orthopaedics. In order to facilitate the medical application of the Bonelike{\textregistered} graft the use of a commercially available polymeric vehicle was also analyzed. Radiological examination, histological studies and scanning electron microscopy (SEM) analyses revealed that the surface of Bonelike{\textregistered} granules was almost completely surrounded by new bone formation after 12 weeks of implantation, which proves its highly osteoconductive behaviour.},
	keywords = {animal model, Animal models, Animals, Biomaterials, Biomedical engineering, Biomimetic materials, Bone, bone tissue, Bonelike graft, Bonelike{\textregistered} graft, Granular materials, In vivo studies, Scanning electron microscopy},
	isbn = {10139826 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33744512103\&partnerID=40\&md5=8f2f8e274f848eb0b105fca4880c0db5},
	author = {Lobato, J.V. and Hussein, N.S. and Botelho, C.M. and Rodrigues, J.M. and Lu{\'\i}s, A.L. and Maur{\'\i}cio, A.C. and Lopes, M.A. and Santos, J.D.}
}
