



@article {2612,
	title = {Investigation of the dissolution of the bioceramic hydroxyapatite in the presence of titanium ions using ToF-SIMS and XPS},
	journal = {BiomaterialsBIOMATERIALS},
	volume = {18},
	year = {1997},
	note = {Cited By (since 1996): 28Export Date: 21 November 2012Source: ScopusCODEN: BIMADdoi: 10.1016/S0142-9612(96)00134-2PubMed ID: 9068892Language of Original Document: EnglishCorrespondence Address: Davies, M.C.; Lab. Biophysics and Surface Analysis, Department Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, United KingdomChemicals/CAS: Biocompatible Materials; Cations; Ceramics; Durapatite, 1306-06-5; Titanium, 7440-32-6References: Hench, L.L., Wilson, J., Bioceramics (1991) MRS Bull, p. 62. , September;Katz, J.L., Harper, R.A., (1990) Concise Encyclopedia of Medical and Dental Materials, p. 87. , ed. D. F. Williams, Pergamon Press, Oxford; 
Posner, A.S., Betts, F., Synthetic amorphous calcium phosphate and its relation to bone mineral structure (1975) Acct Chem Res, 8, p. 2373; 
De Groot, K., (1981) Biocompatibility of Clinical Implant Materials. Vol. I, 1, p. 199. , ed. D. F. Williams, CRC Press, Boca Raton; 
Van Blitterswijk, C.A., Grote, J.J., Kuijpers, W., Daems, W.T., De Groot, K., Macropore tissue ingrowth: A quantitative and qualitative study on hydroxyapatite ceramic (1986) Biomaterials, 7, p. 137; 
Jarcho, M., Calcium phosphate ceramics as hard tissue prosthetics (1981) Clin Orthop Rel Res, 157, p. 259; 
De Groot, K., Geesink, R., Klein, C.P.A.T., Serekian, P., Plasma sprayed coatings of hydroxylapatite (1987) J Biomed Mater Res, 21, p. 1375; 
Kay, J.F., Golec, T.S., Riley, R.L., Hydroxyapatite coated sub-periosteal dental implants: Design rationale and clinical experience (1987) J Prosthet Dent, 58, p. 339; 
Geesink, R.G.T., De Groot, K.A., Klein, C.P.A.T., Chemical implant fixation using hydroxylapatite coatings: The development of a human total hip prosthesis for chemical fixation to bone using hydroxylapatite coatings on titanium substrates (1987) Clin Orthop Rel Res, 225, p. 147; 
Cook, S.D., Thomas, K.A., Kay, J.F., Jarcho, M., Hydroxyapatite coated titanium for orthopaedic implant applications (1988) Clin Orthop Rel Res, 232, p. 225; 
Van Blitterswijk, C.A., Grote, J.J., Kuijpers, Blok-Van Hoek, C.J.G., Daems, W.T., Bioreactions at the tissue/hydroxyapatite interface (1985) Biomaterials, 6, p. 243; 
De Lange, G.L.A., Donath, K., Interface between bone tissue and implants of solid hydroxyapatite-coated titanium implants (1989) Biomaterials, 10, p. 121; 
Craig, G.T., Brook, I.M., Lamb, D.J., Tissue response to subperiosteal implantation of dense hydroxyapatite: Case report (1989) Biomaterials, 10, p. 133; 
Lemons, J.E., Hydroxyapatite coatings (1988) Clin Orthop Rel Res, 235, p. 220; 
Van Blitterswijk, C.A., Grote, J.J., (1989) Critical Reviews in Biocompatibility, 5 (ISSUE 1), p. 13. , CRC Press; 
Driessens, F.C.M., (1983) Bioceramics of Calcium Phosphate, p. 1. , ed. K. de Groot, CRC Press, Boca Raton; 
Van Raemdonck, W., Ducheyne, P., DeMeester, P., (1984) Metal and Ceramic Biomaterials Vol. II, Strength and Surface, 2, p. 143. , eds P. Ducheyne and G. W. Hastings, CRC Press, Boca Raton; 
Lee, D.R., (1988) Dissolution Characterisation of Commercially Available Hydroxylapatite Particulate, , MSc thesis, University of Alabama at Birmingham; 
Whithead, R.Y., Lucas, L.C., Lacefield, W.R., The effect of dissolution on plasma sprayed hydroxylapatite coating on titanium (1993) Clin Materials, 12, p. 31; 
Driessens, F.C.M., Van Dijk, J.W.E., Borggreven, J.M.P.M., Biological calcium phosphates and their role in the physiology of bone and dental tissues I. Composition and solubility of calcium phosphates (1978) Calcif Tiss Res, 26, p. 127; 
LeGeros, R.Z., Tung, M.S., Chemical stability of carbonate and fluoride containing apatites (1983) Caries Research, 17, p. 419; 
Christoffersen, M.R., Thyregood, H.C., Christoffersen, J., Effects of aluminium (III), chromium (II), and iron (III) on the rate of dissolution of calcium hydroxyapatite crystals in the absence and presence of the chelating agent desferrioxamine (1987) J Calcif Tiss Int, 41, p. 27; 
Blumenthal, N.C., Cosma, V., Inhibition of apatic formation by titanium and vanadium ions (1989) J Biomed Mater Res, 23, p. 13; 
Ducheyne, P., Van Raemdonck, W., Heughebaert, J.C., Heughebaert, M., Structural analysis of hydroxyapatite coatings on titanium (1986) Biomaterials, 7, p. 97; 
Ellies, L.G., Nelson, D.G.A., Featherstone, J.D.B., Crystallographic structure and surface morphology of sintered carbonated apatites (1988) J Biomed Mater Res, 22, p. 541; 
Posner, A.S., The structure of bone apatite surfaces (1985) J Biomed Mater Res, 19, p. 241; 
Tudor, A.M., Davies, M.C., Melia, C.D., Anderson, D., Hastings, C., Santos, J.D., Barbosa, M., Morrey, S., The analysis of biomedical hydroxyapatite powders and hydroxyapatite coatings on metallic implant by near-IR Fourier transform Raman spectroscopy (1993) Spectrochimica Acta, 5-6, p. 675; 
Van Raemdonck, W., Ducheyne, P., De Meester, P., Auger electron spectroscopic analysis of hydroxyapatite coatings on titanium (1984) J Am Ceramic Soc, 67, p. 381; 
Smith, D.C., Murray, D.G., Zuccolin, J.D., Ruse, N.D., Surface characteristics of hydroxyapatite and adhesive bonding. 1. Surface characterisation (1987) J Adhesion, 22, p. 291; 
Meachim, G., Williams, D.F., (1973) J Biomed Mater Res, 13, p. 555; 
Pohler, O.E.M., (1983) Biomaterials in Reconstructive Surgery, p. 158. , ed. C. V. Mosby, London; 
Ribeiro, C.C., (1994), MSc. Thesis, University of PortoEccles, A.J., Vickerman, J.C., (1989) J Vac Sci Technol, A7, p. 234; 
Briggs, D., Hearn, M.J., Interaction of ion beams with polymer, with particular respect to SIMS (1986) Vacuum, 36, p. 1005; 
Ribeiro, C.C., Barbosa, M.A., Influence of metal ions on the dissolution behaviour of hydroxyapatite (1991) Bioceramics, 4, p. 145. , eds W. Bonfield, G. H. Hastings and K. E. Tanner, Butterworth-Heinemann; 
Reed, N.M., Vickerman, J.C., (1993) Surface Characterisation of Advanced Polymers, p. 83. , eds L. Sabbatini and P. G. Zambonin, Weinheim, VCH; 
Davies, M.C., Lynn, R.A.P., Paul, A.J., Vickerman, J.C., Heller, J., ToF-SIMS and XPS analysis of the surface chemical structure of some linear poly(ortho esters) (1991) Macromolecules, 24, p. 5508; 
Davies, M.C., Leadley, S.R., Paul, A.J., Vickerman, J.C., Heller, J., Franson, N.M., Probing the surface chemical structure of some novel poly(ortho-esters) prepared with N-methyl and N-phenyl ethanolamine by time-of-flight secondary ion mass spectrometry (ToF-SIMS) (1992) Polymers for Advanced Technologies, 3, pp. 293-301; 
Briggs, D., Ratner, B.D., A semi-quantitative SIMS analysis of the surfaces of random ethyl methacrylate:-Hydroxyethylmethacrylate copolymer films (1988) Polym Comm, 29, p. 6; 
Hearn, M.J., Ratner, B.D., Briggs, D., SIMS and XPS studies of poly(urethane) surfaces. I. Preliminary studies (1988) Macromolecules, 21, p. 2950; 
Briggs, D., Analysis of polymer surfaces by SIMS. VII. Homopolymer and copolymer nylons (1987) Org Mass Spectrom, 22, p. 91
},
	month = {1997///},
	pages = {311 - 316},
	publisher = {Elsevier Science Ltd},
	abstract = {Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS) analyses have been used to investigate the dissolution of hydroxyapatite in the presence of titanium chloride suggesting the substitution of titanium ions for calcium in the hydroxyapatite structure. The surface analytical data suggest that titanium was incorporated within the solid phase as titanium phosphate. Comparison of relative ion intensities in the ToF-SIMS spectra reveals changes in the composition of the surface chemistry of hydroxyapatite. These relative ion intensities show that the maximum surface uptake of titanium occurred at a solution concentration of 500 ppm titanium chloride for a time of incubation of 30 min. These data correlate with that obtained using XPS highlighting the semi-quantitative information which ToF-SIMS can provide.Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS) analyses have been used to investigate the dissolution of hydroxyapatite in the presence of titanium chloride suggesting the substitution of titanium ions for calcium in the hydroxyapatite structure. The surface analytical data suggest that titanium was incorporated within the solid phase as titanium phosphate. Comparison of relative ion intensities in the ToF-SIMS spectra reveals changes in the composition of the surface chemistry of hydroxyapatite. These relative ion intensities show that the maximum surface uptake of titanium occurred at a solution concentration of 500 ppm titanium chloride for a time of incubation of 30 min. These data correlate with that obtained using XPS highlighting the semi-quantitative information which ToF-SIMS can provide.
},
	keywords = {article, Bioceramic hydroxyapatite, Biocompatible Materials, biomaterial, Biomaterials, Cations, ceramic prosthesis, ceramics, Composition, Dissolution, Durapatite, hydroxyapatite, information processing, mass spectrometry, Phosphates, priority journal, Radiography, Secondary ion mass spectrometry, Spectrometry, Mass, Secondary Ion, Spectrometry, X-Ray Emission, Spectrophotometry, Substitution reactions, Surface chemistry, surface property, Surface structure, Time of flight secondary ion mass spectrometry, Time-of-flight secondary ion mass spectrometry, Titanium, Titanium chloride, X ray photoelectron spectroscopy, X-ray photoelectron spectroscopy},
	isbn = {01429612 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0031080821\&partnerID=40\&md5=9581c063071547190645f666a211bddb},
	author = {Leadley, S.R. and Davies, M.C. and Ribeiro, C.C. and Barbosa, M.A. and Paul, A.J. and Watts, J.F.}
}
@article {2629,
	title = {Modifications in the molecular structure of hydroxyapatite induced by titanium ions},
	journal = {Journal of Materials Science: Materials in MedicineJ. MATER. SCI. MATER. MED.},
	volume = {6},
	year = {1995},
	note = {Cited By (since 1996): 22Export Date: 21 November 2012Source: ScopusCODEN: JSMMEdoi: 10.1007/BF00134326Language of Original Document: EnglishCorrespondence Address: Ribeiro, C.C.; Instituto de Engenharia Biomedica, Praca do Coronel Pacheco, 1, 4050 Porto, Portugal},
	month = {1995///},
	pages = {829 - 834},
	publisher = {Chapman \& Hall Ltd},
	abstract = {The purpose of this study was to contribute to the understanding of the effect of titanium ions released from a metallic substrate on the molecular structure of hydroxyapatite. The effects of pH, time of incubation and concentration of titanium ions were investigated. The solids were analysed by X-ray diffraction, Fourier transform infrared spectroscopy, Fourier transform Raman spectroscopy, energy dispersive X-ray analysis and thermogravimetric analysis. The results clearly indicate the presence of a titanium phosphate, Ti(HPO                        4)
                        2{\textperiodcentered}nH
                        2O (n = 1-3), which probably has a double layered structure. The formation of this compound is dependent on the titanium concentration and its crystallinity increases with the time of incubation.
The purpose of this study was to contribute to the understanding of the effect of titanium ions released from a metallic substrate on the molecular structure of hydroxyapatite. The effects of pH, time of incubation and concentration of titanium ions were investigated. The solids were analysed by X-ray diffraction, Fourier transform infrared spectroscopy, Fourier transform Raman spectroscopy, energy dispersive X-ray analysis and thermogravimetric analysis. The results clearly indicate the presence of a titanium phosphate, Ti(HPO
                        4)
                        2{\textperiodcentered}nH
                        2O (n = 1-3), which probably has a double layered structure. The formation of this compound is dependent on the titanium concentration and its crystallinity increases with the time of incubation.
},
	keywords = {Calcium Compounds, Chemical structure, Coatings, conference paper, Crystallinity, Crystallization, Dissolution, Energy dispersive x ray analysis, Fourier transform infrared spectroscopy, Fourier transform Raman spectroscopy, hydroxyapatite, Implants (surgical), incubation time, infrared spectroscopy, Ions, metal ion, Molecular Structure, pH, pH effects, phosphate, Phosphates, priority journal, Raman spectrometry, Raman spectroscopy, Thermogravimetric analysis, thermogravimetry, time, Titanium, Titanium compounds, X ray analysis, X ray diffraction},
	isbn = {09574530 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0029583899\&partnerID=40\&md5=724de7ed1c6fddd7a7e258cd19ba3710},
	author = {Ribeiro, C.C. and Barbosa, M.A. and Machado, A.A.S.C. and Tudor, A. and Davies, M.C.}
}
