



@article {2406,
	title = {Adsorption of albumin on prosthetic materials: Implication for tribological behavior},
	journal = {Journal of Biomedical Materials Research - Part AJ. Biomed. Mater. Res. Part A},
	volume = {78},
	year = {2006},
	note = {Cited By (since 1996): 25Export Date: 21 November 2012Source: ScopusCODEN: JBMRCdoi: 10.1002/jbm.a.30754PubMed ID: 16739106Language of Original Document: EnglishCorrespondence Address: Serro, A.P.; Centro de Qu{\'\i}mica Estrutural, Instituto Superior T{\'e}cnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal; email: anapaula.serro@ist.utl.ptChemicals/CAS: aluminum oxide, 1302-74-5, 1318-23-6, 1344-28-1, 14762-49-3; iodine 125, 14158-31-7, 22822-81-7; molybdenum, 7439-98-7; protein, 67254-75-5; stainless steel, 12597-68-1; Albumins; Biocompatible MaterialsTradenames: CHIRULEN, Poly Hi Solidur, GermanyManufacturers: Maret, Switzerland; MediMet, Germany; Poly Hi Solidur, GermanyReferences: Widmer, M.R., Heuberger, M., V{\"o}r{\"o}s, J., Spencer, N.D., Influence of polymer surface chemistry on frictional properties under protein-lubrication conditions: Implications for hip-implant design (2001) Tribol Lett, 10, pp. 111-116;Saikko, V., Effect of lubricant protein concentration on the wear of ultrahigh molecular weight polyethylene sliding against a CoCr counterface (2003) Trans ASME, 125, pp. 638-642; 
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Kumar, P., Oka, M., Ikeuchi, K., Shimizu, K., Yamamuro, T., Okumura, H., Kotoura, Y., Low wear rate of UHMWPE against zirconia ceramic (Y-PSZ) in comparison to alumina ceramic and SUS 316L alloy (1991) J Biomed Mater Res, 25, pp. 813-828; 
Kitano, T., Ateshian, G.A., Mow, V.C., Kadoya, Y., Yamano, Y., Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial cartilage (2001) J Biomech, 34, pp. 1031-1037; 
Gispert, M.P., Serro, A.P., Cola{\c c}o, R., Saramago, B., Friction and wear mechanisms in hip prosthesis: Comparison of joint materials behaviour in several lubricants (2006) Wear, 260, pp. 149-158; 
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Rubio, C., Costa, D., Bellon-Fontaine, M.N., Relkin, P., Pradier, C.M., Marcus, P., Characterization of bovine serum albumin adsorption on chromium and AISI 304 stainless steel, consequences for the Pseudomonas fragi K1 adhesion (2002) Colloid Surf B Biointerface, 24, pp. 193-205; 
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},
	month = {2006///},
	pages = {581 - 589},
	abstract = {The orthopedic prosthesis used to substitute damaged natural joints are lubricated by a pseudosynovial fluid that contains biological macromolecules with potential boundary lubrication properties. Proteins are some of those macromolecules whose role in the lubrication process is not yet completely understood. In a previous work, we investigated the influence of the presence of albumin, the major synovial protein, upon the tribological behavior of three of the most used pairs of artificial joint materials: ultra high molecular weight polyethylene (UHMWPE) against counterfaces of alumina, CoCrMo alloy, and 316L stainless steel. Albumin was found to cause a significant decrease in the friction coefficient when the counterfaces were metallic because transfer of UHMWPE was avoided, but this effect was much weaker in the case of alumina. The objective of the present work was to look for an explanation for these differences in tribological behavior in terms of albumin adsorption. With this goal, studies on adsorption of bovine serum albumin (BSA) on the counterface materials, from a biological model fluid (Hanks{\textquoteright} balanced salt solution), were carried out using radiolabeled albumin (                        125I-BSA), X-ray photoelectron spectroscopy, and atomic force microscopy. The conclusion from all techniques is that the driving force for albumin adsorption is higher on the metals than on alumina. These results confirm that the greater the amount of protein adsorbed on the counterface, the more efficient is the protection against the transfer of polymeric film to the counterface. {\textcopyright} 2006 Wiley Periodicals, Inc.
},
	keywords = {Adsorption, Albumin, Albumin adsorption, Albumins, Alumina, aluminum oxide, article, Atomic force microscopy, balanced salt solution, Biocompatible Materials, Body fluids, bovine serum albumin, chromium derivative, Cobalt alloy, Cobalt alloys, cobalt derivative, force, Friction, iodine 125, isotope labeling, joint fracture, Joints (anatomy), lubrication, macromolecule, metal, molecular weight, molybdenum, orthopedic prosthesis, orthopedics, Polyethylenes, polymer, Prostheses and Implants, prosthesis material, Prosthetics, protein, Proteins, Pseudosynovial fluid, Stainless steel, Thermodynamics, Tribology, ultra high molecular weight polyethylene, Ultra high molecular weight polyethylene (UHMWPE), X ray photoelectron spectroscopy},
	isbn = {00219304 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33747426950\&partnerID=40\&md5=1728518c691365be3d5b3733dec3d60f},
	author = {Serro, A.P. and Gispert, M.P. and Martins, M.C.L. and Brogueira, P. and Cola{\c c}o, R. and Saramago, B.}
}
@article {2553,
	title = {Concept, design and fabrication of smart orthopedic implants},
	journal = {Medical Engineering and PhysicsMed. Eng. Phys.},
	volume = {22},
	year = {2000},
	note = {Cited By (since 1996): 29Export Date: 21 November 2012Source: ScopusCODEN: MEPHEdoi: 10.1016/S1350-4533(00)00062-XPubMed ID: 11165144Language of Original Document: EnglishCorrespondence Address: Burny, F.; Service d{\textquoteright}Orthopedie-Traumatologie, Cliniques Universitaires Bruxelles, H{\^o}pital Erasme, Brussels, Belgium; email: fburny@ulb.ac.beChemicals/CAS: Biocompatible Materials; Ceramics; Metals; Stainless Steel, 12597-68-1References: Burny, F., Donkerwolcke, M., Moulart, F., Clinical application of the monitoring of orthopedic implants (1993), pp. 138-146. , Burny R, Puers F, editors. Monitoring of orthopedic implants. A biomaterials microelectronics - challenge. Amsterdam: ElsevierBurny, F., Zucman, J., Bourgois, R., Aubriot, J.H., Sedel, J., Utilisation des jauges extensom{\'e}triques pour la mesure de la consolidation des fractures du tibia trait{\'e}es par enclouage centrom{\'e}dullaire. Etude th{\'e}orique et premiers r{\'e}sultats (1971) Acta Orthop Belg, 37, pp. 266-277;Moulart, F., (1975) R{\'e}{\'e}ducation des fractures hautes du f{\'e}mur. Mesure des d{\'e}formations du mat{\'e}riel d{\textquoteright}ost{\'e}osynthese, , M{\'e}moire de Licence en Kin{\'e}sith{\'e}rapie, Universit{\'e} Libre de Bruxelles; 
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Burny, F., Donkerwolcke, M., Telemetry in the musculoskeletal system (1991), pp. 391-394. , Payne PA, editor. Concise encyclopedia of biological and biomedical measurement systems. Oxford: Pergamon PressPuers, R., Burny, F., Biotelemetry in orthopaedics (1992), 3, pp. 285-306. , Muster D. et al., editors. European Materials Research Society Monographs. Biomaterials. Hard Tissue Repair and Replacement, Amsterdam: ElsevierKadefors, R., Kaiser, E., Petersen, I., Energizing implantable transmitters by means of coupled inductance coils (1969) IEEE Trans Biomed Eng, 16 BME, pp. 177-183; 
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},
	month = {2000///},
	pages = {469 - 479},
	abstract = {Extensive clinical experience has been built up using orthopaedic implants instrumented with strain gauges connected to a Wheatstone bridge by means of percutaneous leads. This research showed the medical relevance of the monitoring of the deformation of implants as a powerful tool to evaluate nursing and rehabilitation exercises, for tracing dangerous overloads and anticipating implant failure and also to observe the healing process. The IMPACT 3500 project focuses on the instrumentation of femoral implants with on board sensors: regular Benoist-Girard implants have been modified, to contain a {\textquoteright}sensing cell{\textquoteright}, and thoroughly tested in vitro and in vivo. The implant deformations are measured with resistive strain gauges, and the signal is transferred to a personal computer for processing and display, via a hard wired connection, or via a telemetry system. Two fully implantable wireless designs, called Linkstrain and Sealstrain, are powered from the outside by magnetic induction. As Sealstrain contains the whole telemetric system in its cavity, the highest miniaturization was required; this seriously deteriorates the efficiency of the inductive power link. {\textcopyright} 2001 IPEM.},
	keywords = {article, atomic absorption spectrometry, Biocompatible Materials, biomechanics, body movement, Bone Plates, ceramics, compression, Corrosion, Failure of implants, Femoral Fractures, femur, Fracture healing, healing, Humans, materials testing, metal, metal implantation, Metals, microcomputer, Microscopy, Electron, Scanning, Monitoring, Physiologic, Orthopedic implants, orthopedic surgery, priority journal, Prostheses and Implants, Prosthesis Design, prosthesis failure, Rehabilitation, Scanning electron microscopy, sensor, Sensors, Smart implants, Spectrum Analysis, Stainless steel, strain gauge transducer, Strain measurements, Stress, Mechanical, Telemetry, Weight-Bearing},
	isbn = {13504533 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-20244372369\&partnerID=40\&md5=456fea60c077d9bd4569169438349a07},
	author = {Burny, F. and Donkerwolcke, M. and Moulart, F. and Bourgois, R. and Puers, R. and Van Schuylenbergh, K. and Barbosa, M. and Paiva, O. and Rodes, F. and B{\'e}gueret, J.B. and Lawes, P.}
}
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},
	month = {1996///},
	pages = {77 - 83},
	publisher = {Chapman \& Hall Ltd},
	abstract = {Fibroblasts from normal human skin were cultured for a period of 21 days in the absence or in the presence of metal ions. The effects of stainless steel (SS) corrosion products were compared to the effects of iron, chromium and nickel ions used either separately (Fe, Cr, or Ni solutions) or combined (Fe+Cr+Ni solution). At several periods of time (4, 7, 14 and 21 days) the cell cultures were analysed for the following parameters: (a) metal ion accumulation by atomic absorption spectrometry; (b) cell morphology and viability by the neutral red assay; (c) cell proliferation by DNA assessment, and enzyme activity by both (d) MTT reduction and (e) acid phosphatase activity. Results showed that SS-corrosion products and the corresponding metal ions combined at the same concentrations, Fe+Cr+Ni solution, had opposite effects on fibroblast cultures. In fact, SS-corrosion products caused no apparent effects on cell morphology nor on cell proliferation whereas Fe+Cr+Ni solution stimulated both neutral red uptake and cell proliferation. The enzymatic assays showed that SS-corrosion products caused inhibition of both MTT reduction and acid phosphatase activity in contrast to Fe+Cr+Ni solution which stimulated their activity. Furthermore, in all biological parameters studied, a strong association was observed between the effects of Fe+Cr+Ni solution and Cr alone, suggesting that Cr was the metal ion mostly involved in the stimulatory effects of the combined solution.Fibroblasts from normal human skin were cultured for 21 days in the absence, or presence, of metal ions. The effects of stainless steel (SS) corrosion products were compared to the effects of iron, chromium, and nickel ions used either separately or combined. At different periods of time, the cell cultures were analyzed for the following parameters: metal ion accumulation by atomic absorption spectrometry; cell morphology and viability by the neutral red assay; cell proliferation by DNA assessment; and enzyme activity by both MTT reduction and acid phosphatase activity. Results show that SS-corrosion products and the corresponding metal ions combined at the same concentrations, Fe+Cr+Ni solution, have opposite effects on fibroblast cultures.
},
	keywords = {3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide, Absorption spectroscopy, Acid phosphatase, article, atomic absorption spectrometry, Atomic spectroscopy, Bioassay, Cell culture, Cell morphology, cell proliferation, cell structure, cell viability, Chromium, controlled study, Corrosion, Corrosion products, cytology, DNA, Enzymatic assays, Enzyme Activation, enzyme activity, Enzyme inhibition, fibroblast, human, human cell, Ions, Iron, metal, Metal ion accumulation, Metal salts, Metals, neutral red, Nickel, priority journal, Salts, Skin, skin fibroblast, Stainless steel, Steel corrosion},
	isbn = {09574530 (ISSN)},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0030087165\&partnerID=40\&md5=a26cd67a43c1fef54a5df943014fd7c6},
	author = {Carvalho, G.S. and Castanheira, M. and Diogo, I. and Abreu, A.M. and Sousa, J.P. and Loon, J.A. and Van Blitterswijk, C.A.}
}
