| Title | Fabrication of alternating polycation and albumin multilayer coating onto stainless steel by electrostatic layer-by-layer adsorption |
| Publication Type | Journal Article |
| 2004 |
| Authors | Ji, J, Tan, Q, Fan, D-Z, Sun, F-Y, Barbosa, MA, Shen, J |
| Journal | Colloids and Surfaces B: BiointerfacesColloids Surf. B Biointerfaces |
| Volume | 34 |
| Issue | 3 |
| Pagination | 185 - 190 |
| Date Published | 2004/// |
| 09277765 (ISSN) |
| Adhesion, Adsorption, Albumin, Albumins, article, Atomic force microscopy, Cardiovascular devices, Chemical modification, Coatings, Electric Impedance, Electric Potential, Electrochemical impedance spectroscopy, electrochemistry, Electrons, Electrostatics, film coating, iodine 125, isotope labeling, Layer-by-layer, Lipid Bilayers, Microscopy, Atomic Force, Multilayers, Nonthrombogenic, pH effects, Platelet Adhesiveness, Polyamines, polycation, Polycations, Polyethyleneimine, priority journal, Proteins, Self assembly, Spectroscopy, Spectrum Analysis, Stainless steel, Surface modification, Surface Properties, surface property, Surface treatment, thrombocyte adhesion |
| Multilayer films consisting of polyethylenimine (PEI) and albumin were successfully prepared on biomedical 316L stainless steel surface via electrostatic self-assembly of the PEI and albumin. The process of electrostatic self-assembly of PEI/albumin was monitored by 125I radiolabeling, electrochemical impedance spectroscopy (EIS) and atomic force microscopy (AFM). The EIS data revealed that the multilayer coating was stable in Tris-HCl (pH 7.35) buffer solution for 21 days.
125I radiolabeling experiments indicated that less than 10% albumin was eluted by PBS in 45 days. Static platelet adhesion experiments indicated that the PEI/albumin deposited on stainless steel could resist platelet adhesion effectively. Such an easy processing and shape-independent method may have good potential for surface modification of cardiovascular devices. © 2004 Elsevier B.V. All rights reserved.
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