| Title | Frequency domain and entropy analysis of fetal heart rate: Appealing tools for fetal surveillance and pharmacodynamic assessment of drugs |
| Publication Type | Journal Article |
| 2008 |
| Authors | Gonçalves, H, Rocha, AP, Ayres-de-Campos, D, Bemardes, J |
| Journal | Cardiovascular and Hematological Disorders - Drug TargetsCardiovasc. Hematol. Disord. Drug Targets |
| Volume | 8 |
| Issue | 2 |
| Pagination | 91 - 98 |
| Date Published | 2008/// |
| 1871529X (ISSN) |
| acidemia, adrenergic receptor stimulating agent, alpha adrenergic receptor blocking agent, anticonvulsive agent, article, atropine, autonomic nervous system function, beta adrenergic receptor blocking agent, betamethasone, Cardiotocography, central depressant agent, central nervous system function, cholinergic receptor blocking agent, chronotropism, Computerized analysis, drug effect, drug mechanism, electronic sensor, entropy, External and internal monitoring, Female, Fetal behavioral states, Fetal heart rate (FHR), Fetal monitoring, fetus, fetus heart rate, fetus monitoring, frequency analysis, Frequency domain and entropy analysis, gestation period, Heart rate variability, Heart Rate, Fetal, human, Humans, instrumentation, labor, lidocaine, local anesthetic agent, magnesium sulfate, mathematical computing, methodology, nonhuman, opiate, pharmacodynamics, physiology, Pregnancy, prenatal screening, propranolol, pulse rate, review, salbutamol, signal detection |
| Recently, frequency domain and entropy analysis of fetal heart rate (FHR) have been assessed in several studies, providing new insights into physiologic regulatory mechanisms, constituting appealing tools for pharmacodynamic assessment, namely during fetal life. There is evidence that entropy and frequency domain analysis convey information on cortical and autonomic nervous system activities, respectively. Use of internal versus external FHR acquisition sensors and the signal sampling frequency may dramatically affect results. Most FHR frequency domain indices are significantly increased with rising fetal activity, namely during active wakefulness and active sleep, whereas the opposite occurs with nonlinear indices. This is in favour of increased activity of the autonomous nervous system and decreased activity of the central nervous system complexity control systems, during periods of fetal activity. Progression of labor is associated with a significant increase in FHR frequency domain indices, whereas entropy indices are significantly decreased. This denotes activation of the autonomic nervous system in the final minutes of labour, associated with decreased central nervous system activity. The emerging knowledge on FHR frequency domain and entropy analysis substantiates a continued interest of these methods in evaluation of the fetal pathophysiologic regulatory mechanisms, and opens new perspectives for clinical and pharmacodynamic assessment. © 2008 Bentham Science Publishers Ltd. |
