| Title | NPY signalling pathway in bone homeostasis: Y1 receptor as a potential drug target |
| Publication Type | Journal Article |
| 2009 |
| Authors | Sousa, DM, Herzog, H, Lamghari, M |
| Journal | Current Drug TargetsCurr. Drug Targets |
| Volume | 10 |
| Issue | 1 |
| Pagination | 9 - 19 |
| Date Published | 2009/// |
| 13894501 (ISSN) |
| 1 [1 [3 [(3 piperidyl)]]propyl] 2 [[(4 chlorophenoxyl)methyl]indol 3 yl] 2 (4 piperidylpiperidyl)ethan 1 one, 2 [1 (3 chloro 5 isopropoxycarbonylaminophenyl)ethylamino] 6 [2 (5 ethyl 4 methyl 2 thiazolyl)ethyl] 4 morpholinopyridine, 2 [1 (3 chloro 5 isopropyloxycarbonylaminophenyl)ethylamino] 6 [2 (5 ethyl 4 methyl 1,3 thiazol 2 yl)ethyl] 4 morpholinopyridine, Amino Acid Sequence, animal, Animals, bone development, bone mass, bone remodeling, Bone remodelling, bone turnover, Brain, drug antagonism, drug effect, drug potentiation, drug targeting, genetics, gi 264879a, gr 231118, Homeostasis, human, Humans, ligand, Ligands, ly 357897, metabolism, molecular genetics, Molecular Sequence Data, n alpha [3,3 bis(1 naphthyl)propionyl]dextro arginine n [1 benzyl 2 methoxyethyl]amide, n [1 [4 [[[[4 [(dimethylamino)methyl]cyclohexyl]methyl]amino]iminomethyl]benzyl] 2 oxo 2 (1 pyrrolidinyl)ethyl] alpha [(2 naphthalenylsulfonyl)amino]benzenepropanamide, n2 diphenylacetyl n (4 ureidomethylbenzyl)argininamide, nalpha (diphenylacetyl) n (4 hydroxybenzyl) dextro argininamide, neuropeptide Y, neuropeptide Y receptor, neuropeptide Y receptor agonist, neuropeptide Y receptor antagonist, neuropeptide Y [25 dextro arginine], neuropeptide Y [26 dextro histidine], neuropeptide Y [31 leucine 34 proline], neuropeptide Y [6 arginine 34 proline], neuropeptide Y [7 phenylalanine 34 proline], neuropeptide Y1 receptor, neuropeptide Y2 receptor, neuropeptide Y4 receptor, neuropeptide Y5 receptor, neuropeptide Y6 receptor, nonhuman, osteoblast, osteoclast, osteolysis, peptide YY, peptide YY [31 leucine 34 proline], peptide YY [34 proline], pharmacological blocking, physiology, protein binding, protein expression, protein family, protein isolation, receptor intrinsic activity, Receptors, Neuropeptide Y, review, signal transduction, unclassified drug, Y1 receptor |
| Neuropeptide (NPY) is a neurotransmitter widely distributed in central and peripheral nervous system that has been implicated in several physiological processes through activation of five different Y receptors: Y1, Y2, Y4, Y5, and y6. NPY system has been extensively studied for the last decades due to its implications in a wide variety of physiological processes. For this purpose a diversity of sophisticated animal models and receptors agonists and antagonists has been developed to better understand its actions throughout body homeostasis. Consequently, NPY and its receptors have recently emerged as a potential regulator of bone homeostasis. This is supported by the demonstration of an increase of bone mass in mice lacking Y1 or Y2 receptor genes. Recent findings revealed Y1 receptor as a potential drug target candidate for prevention and treatment of bone loss. Indeed, it has been demonstrated that osteoblasts express Y1 receptor while no other Y receptor was detected in these cells, implicating Y1 receptor signalling in the local control of bone turnover. In this review, we have summarized the findings obtained from studies on NPY system in skeletogenesis focusing on Y1 receptor. © 2009 Bentham Science Publishers Ltd. |
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