| Title | Porous Hydroxyapatite and Glass Reinforced Hydroxyapatite for Controlled Release of Sodium Ampicillin |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Queiroz, AC, Teixeira, S, Santos, JD, Monteiro, FJ |
| Series Editor | M.A., B, F.J., M, R., C, B., L |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 254-256 |
| Number of Pages | 997 - 1000 |
| City | Porto |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Adsorption, Antibiotics, Coatings, Dense materials, Diseases, Drug delivery, Drug dosage, Fourier transform infrared spectroscopy, glass, Glass reinforced hydroxyapatite, hydroxyapatite, Mercury (metal), Porous, Porous materials, Scanning electron microscopy, Sodium, Strength of materials, Ultraviolet spectroscopy, X ray diffraction analysis |
| Abstract | Porous hydroxyapatite (HA) and glass reinforced hydroxyapatite (GRHA) with adequate macro and microporous structure were developed, aiming at being used as drug delivery carrier of antibiotics, for the in situ treatment of periodontitis. Materials were characterised by XRD and FTIR, presenting no changes from similar dense materials. Mercury intrusion porosimetry revealed micropores of less than 1 μm, accounting for 15% of the total porosity. Compression tests have shown close values for HA and GRHA, with the former showing slightly higher values of strength. Ampicillin adsorption was more effective on porous than on dense HA, and was similar for HA and GRHA. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0347516111&partnerID=40&md5=a85b6393d2a4a2d3ee4b384bf4c3de78 |
