| Title | Preparation of albumin preferential surfaces on poly(vinyl chloride) membranes via surface self-segregation |
| Publication Type | Journal Article |
| 2002 |
| Authors | Ji, A, Feng, L, Shen, J, Barbosa, MA |
| Journal | Journal of Biomedical Materials ResearchJ. Biomed. Mater. Res. |
| Volume | 61 |
| Issue | 2 |
| Pagination | 252 - 259 |
| Date Published | 2002/// |
| 00219304 (ISSN) |
| Adsorption, Albumin, Amphiphilic copolymer, amphophile, aqueous solution, article, artificial membrane, Biocompatible Materials, cell separation, cell surface, chemical binding, combinatorial chemistry, concentration response, conference paper, dimerization, energy resource, film, human, Humans, infection, Inflammation, Inflammations, macrogol, macrogol derivative, membrane structure, Membranes, Artificial, metabolism, Plastic films, Polyethylene Glycols, polymer, Polymeric membranes, Polyvinyl Chloride, Polyvinyl chlorides, polyvinylchloride, protein binding, Serum Albumin, Stearates, stearic acid derivative, stearyl poly(ethylene oxide), Surface modification, Surface Properties, surface property, Surface segregation, Synthesis (chemical), thrombosis, X ray analysis, X ray photoelectron spectroscopy |
| Poly(vinyl chlorides)-graft-[w-stearyl-poly(ethylene oxide)] (PVC-g-SPEO), which has a poly(vinyl chloride) (PVC) backbone, poly(ethylene oxide) (PEO) side chain, and stearyl end groups, has been synthesized. Self-organizing blends of the amphiphilic comb polymer in poly-(vinyl chlorides) have been examined as a means to create albumin preferential surfaces on polymer films. X-ray photoelectron spectroscopy (XPS) analysis indicates substantial surface segregation of the PVC-g-SPEO. A surface concentration of 59.9 EO wt % is achieved by the solution casting and heat treatment of a film with a bulk concentration of only 3.78 EO wt %. In the aqueous environment, the surface rearrangement of PVC-g-SPEO/PVC blend film is limited and presents a high interfacial energy and high depolar component of interfacial energy due to the "tail-like" SPEO side chain. Protein adsorption tests confirm that PVC-g-SPEO/PVC blend films absorb high levels of albumin and dramatically resist fibrinogen adsorption. Surfaces to attract and reversibly bind albumin, which might diminish the occurrence of thrombosis, inflammation, and infection, are developed by self-organizing blends of the amphiphilic comb polymer in poly(vinyl chlorides). © 2002 Wiley Periodicals, Inc. |
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