| Title | Production of porous hydroxyapatite with potential for controlled drug delivery |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Queiroz, AC, Teixeira, S, Santos, JD, Monteiro, FJ |
| Series Editor | R., M, E., F, I., F, C., D |
| Series Title | Materials Science ForumMater Sci Forum |
| Volume | 455-456 |
| Number of Pages | 358 - 360 |
| City | Caparica |
| ISBN Number | 02555476 (ISSN) |
| Keywords | Adsorption, Antibiotics, Bioceramics, Controlled drug delivery, Drug Carriers, Drug delivery, Fourier transform infrared spectroscopy, hydroxyapatite, morphology, Polyurethanes, porosity, Porous, Porous materials, Scanning electron microscopy, X ray diffraction analysis |
| Abstract | Porous hydroxyapatite was prepared in order to be used as a drug carrier and promote bone ingrowth. For this purpose, the microstructure should have interconnective pores and micro as well as macro porosity, for bone cell adhesion and bone ingrowth. The porous hydroxyapatite prepared by the burn-out method exhibits all these features. For measuring porosity, SEM analysis, mercury intrusion porosimetry and BET were used. FT-IR and XRD analysis revealed that only hydroxyapatite phase was present, being this result similar to the one found for dense samples. The morphology obtained appears to be well adapted to bone growth and drug adsorption. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-17044442244&partnerID=40&md5=7baa6f22534360d57deb7862546fb275 |
