INEB
INEB
TitleSilicon and iron levels in tissues of animals treated with a "ferrimagnetic ceramic" with oncotherapeutic potential (anti-tumor) value
Publication TypeJournal Article
2002
AuthorsAlmeida, T, Soares, ME, Cavalheiro, J, Bastos, MDL
JournalJournal of Trace Elements in Medicine and BiologyJ. Trace Elem. Med. Biol.
Volume16
Issue4
Pagination255 - 259
Date Published2002///
0946672X (ISSN)
animal model, animal tissue, Animalia, Animals, article, atomic absorption spectrometry, Biocompatible Materials, calcium oxide, cancer therapy, cement, ceramics, controlled study, experimental model, Ferrimagnetic ceramic, heat, Humans, implant, Iron, Magnetics, materials testing, Neoplasms, nonhuman, Oncotherapy, phosphorus pentoxide, powder, priority journal, Prostheses and Implants, rat, Rats, Reproducibility of Results, Silicon, silicon dioxide, tissue distribution, Tissue Extracts
The stability in a biological environment of an injectable cement with oncotherapeutic potential - consisting of a glass powder of SiO 2 (35.6%), CaO (42.4%), P 2O 5 (17%), Na 2O (5%) and 30% of its weight of Fe 3O 4 dissolved in (NH 4) 2HPO 4 plus NH 4H 2PO 4 - was evaluated referring to the release of silicon and iron. The experimental model was the rat, and organs (liver, kidney, spleen, lung, heart, and brain) of the implanted and control animals were collected for quantification of these elements by electrothermal atomization atomic absorption spectrometry methods. In most of the analysed organs no significant difference in the contents of silicon and iron between the implanted and the control animals was found.
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