| Title | In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Shirosaki, Y, Tsuru, K, Hayakawa, S, Osaka, A, Lopes, MA, Santos, JD, Fernandes, MH |
| Series Editor | M.A., B, F.J., M, R., C, B., L |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 254-256 |
| Number of Pages | 857 - 860 |
| City | Porto |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Biocompatibility, Biological membranes, biosynthesis, Cell culture, Cells, chitosan, Chitosan-inorganic hybrid, Crosslinking, Cytocompatibility, Fourier transform infrared spectroscopy, Nuclear magnetic resonance spectroscopy, Organic polymers, Osteoblastic cell (MG63), Structural analysis, Synthetic polymers, Tissue, Tissue engineering, γ-Glycidoxypropyltrimethoxysilane (GPSM) |
| Abstract | Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0346885502&partnerID=40&md5=80d45c86bb14c57c3b1a6b94b435e45d |
