| Title | In vitro degradation behavior of a novel bioresorbable composite material based on PLA and a soluble CaP glass |
| Publication Type | Journal Article |
| 2005 |
| Authors | Navarro, M, Ginebra, MP, Planell, JA, Barrias, CC, Barbosa, MA |
| Journal | Acta BiomaterialiaActa Biomater. |
| Volume | 1 |
| Issue | 4 |
| Pagination | 411 - 419 |
| Date Published | 2005/// |
| 17427061 (ISSN) |
| Absorbable Implants, Absorption, article, biodegradability, Biodegradable composite, Biomimetic materials, Body fluids, Bone Regeneration, Bone Substitutes, calcium phosphate, Calcium phosphates, composite material, Degradation, electron microscopy, glass, In vitro degradation, in vitro study, Lactic Acid, materials testing, molecular weight, observation, Phosphate glass, polylactic acid, Polymers, precipitation, priority journal, reaction analysis, simulation, Solubility, Surface Properties, surface property, temperature, weight reduction |
| Poly(α-hydroxy acids), and in particular polylactic acid (PLA), are nowadays amongst the most used bioabsorbable materials. However, this polymer may not meet some application requirements due to inadequate mechanical properties and or its degradation characteristics. A possible strategy to tackle this problem is the incorporation of an inorganic phase into the polymeric matrix. In this work a new fully biodegradable composite material made with PLA and calcium phosphate soluble glass particles has been developed. The behaviour of the PLA/ glass composite has been analysed during its degradation in simulated physiological conditions by means of weight loss, molecular weight and thermal properties analysis and electron microscopy observation. The results showed that the incorporation of phosphate glass particles into the polymer significantly accelerated the degradation of the PLA and induced the formation of calcium phosphate precipitates at the composite surface. © 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
