| Title | In Vitro Mineralisation of Human Bone Marrow Cells Cultured on Bonelike® |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Costa, MA, Gutierres, M, Almeida, L, Lopes, MA, Santos, JD, Fernandes, MH |
| Series Editor | M.A., B, F.J., M, R., C, B., L |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 254-256 |
| Number of Pages | 821 - 824 |
| City | Porto |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Bone, Bonelike®, Cell culture, cell proliferation, Composition, Grafts, Human bone marrow cells, hydroxyapatite, In vitro mineralisation, mineralization, Scanning electron microscopy, Sintering, X ray diffraction |
| Abstract | Bonelike® is a CaO-P 2O
5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike® concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike® allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike® had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.
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| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0346255201&partnerID=40&md5=470ac94fd75d1a53b887d44f59fbf7d1 |
