| Title | In Vivo Behaviour of Bonelike®/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation |
| Publication Type | Book |
| Year of Publication | 2004 |
| Authors | Oliveira, JM, Kawai, T, Lopes, MA, Ohtsuki, C, Santos, JD, Afonso, A |
| Series Editor | M.A., B, F.J., M, R., C, B., L |
| Series Title | Key Engineering MaterialsKey Eng Mat |
| Volume | 254-256 |
| Number of Pages | 565 - 568 |
| City | Porto |
| ISBN Number | 10139826 (ISSN) |
| Keywords | Biodegradation, Bonelike®, Computerized tomography, Histological analysis, histology, hydroxyapatite, In vivo studies, Organic polymers, PLGA, pQ-CT, Silanes, Sintering, Synthetic polymers, Tibiae implantations, Tissue |
| Abstract | The present work consisted in assessing the in vivo biological behaviour of novel Bonelike®/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike® resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike® have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike®. This result is strongly encouraging since Bonelike®/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0346255223&partnerID=40&md5=1d0c1ad508daa6b14d2d3aeabf5fff65 |
