INEB RECENT PUBLICATIONS: The role of the surface on microglia function: implications for central nervous system tissue engineering

INEB researchers recently published an article in the Journal of the Royal Society Interface, available since 24 December 2014. The article is entitled "The role of the surface on microglia function: implications for central nervous system tissue engineering" and is authored by Pires LR, Rocha DN, Ambrosio L, Pêgo AP.

In tissue engineering, it is well accepted that a scaffold surface has a decisive impact on cell behaviour. Here we focused on microglia – the resident immune cells of the central nervous system (CNS) – and on their response to poly(trimethylene carbonate-co-ε-caprolactone) [P(TMC-CL)] fibrous and flat surfaces obtained by electrospinning and solvent cast, respectively. This study aims to provide cues for the design of instructive surfaces that can contribute to the challenging process of CNS regeneration.