RECENT PUBLICATIONS: New insights on the mitochondrial proteome plasticity in Parkinson's disease

INEB researchers recently published an article in the journal Proteomics Clinical Applications, available in press since April 2016. The article is entitled "New insights on the mitochondrial proteome plasticity in Parkinson's disease" and is authored by Miguel Aroso, Rita Ferreira, Ana Freitas, Rui Vitorino and María Gomez-Lázaro.

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Despite its unknown etiology is widely accepted the involvement of the mitochondria in the pathobiology of this disorder. The paper describes how the authors have performed network analysis from the available data obtained by mass spectrometry-based proteomics. Despite the well-known involvement of the deficiency of the complex I from the mitochondrial electron transport, data retrieved from our analysis highlighted the modulation of the biological processes related with “generation of energy,” “cellular metabolism,” and “mitochondrial transport” in Parkinson’s disease.