



@article {3278,
	title = {Dysregulation of T cell receptor N-glycosylation: A molecular mechanism involved in ulcerative colitis},
	journal = {Human Molecular Genetics},
	volume = {23},
	year = {2014},
	note = {Export Date: 21 November 2014},
	month = {2014},
	pages = {2416 - 2427},
	abstract = {The incidence of inflammatory bowel disease is increasing worldwide and the underlying molecular mechanisms are far from being fully elucidated. Herein, we evaluated the role of N-glycosylation dysregulation in T cells as a key mechanism in the ulcerative colitis (UC) pathogenesis. The evaluation of the branched N-glycosylation levelsandprofile of intestinalTcell receptor (TCR)wereassessedin colonic biopsies fromUCpatientsand healthy controls. Expression alterations of the glycosyltransferase gene MGAT5 were also evaluated. We demonstrated thatUCpatients exhibit a dysregulation ofTCRbranchedN-glycosylationonlamina propriaTlymphocytes. Patients with severe UC showed the most pronounced defect on N-glycan branching in T cells. Moreover, UC patients showed a significant reduction of MGAT5 gene transcription in T lymphocytes. In this study, we disclose for the first time that a deficiency in branched N-glycosylation on TCR due to a reduced MGAT5 gene expression is a new molecular mechanism underlying UC pathogenesis, being a potential novel biomarker with promising clinical and therapeutic applications. {\textcopyright} The Author 2013. Published by Oxford University Press. All rights reserved.},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84897565140\&partnerID=40\&md5=4ee6b5b3f85e16eba322ceb8e0d69dd3},
	author = {Dias, A.M. and Dourado, J. and Lago, P. and Cabral, J. and Marcos-Pinto, R. and Salgueiro, P. and Almeida, C.R. and Carvalho, S. and Fonseca, S. and Lima, M. and Vilanova, M. and Dinis-Ribeiro, M. and Reis, C.A. and Pinho, S.S.}
}
