| Title | Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite composites |
| Publication Type | Journal Article |
| 2001 |
| Authors | Queiroz, AC, Santos, JD, Monteiro, FJ, Gibson, IR, Knowles, JC |
| Journal | BiomaterialsBiomaterials |
| Volume | 22 |
| Issue | 11 |
| Pagination | 1393 - 1400 |
| Date Published | 2001/// |
| 01429612 (ISSN) |
| Adsorption, ampicillin, Antibiotics, article, calcium phosphate, composite material, controlled study, drug adsorption, Drug delivery, drug delivery system, Drug release, Durapatite, glass, Glass-reinforced hydroxyapatite, hydroxyapatite, Kinetics, Microstructure, Penicillins, periodontitis, priority journal, Reinforcement, Rietveld analysis, roentgen spectroscopy, Sodium ampicillin, Sodium compounds, structure analysis, unclassified drug, X ray diffraction, X ray diffraction analysis, X ray photoelectron spectroscopy, X-Ray Diffraction |
| As a potential therapy for periodontitis, sodium ampicillin, a broad spectrum antibiotic, was adsorbed onto hydroxyapatite (HA) and glass-reinforced hydroxyaptite (GR-HA) composites, and was subsequently released in vitro. The sodium ampicillin, was adsorbed more on HA compared to the GR-HA composites. X-ray diffraction (XRD) and Rietveld analysis were used to identify and quantify the levels of HA and β-tricalcium phosphate (β-TCP) in the microstructure of the GR-HA composites. Lattice parameters changes were observed for the β-TCP phase dependant on the amount of glass added. The release kinetics were shown to be divided into three stages, the first of which where a large amount of sodium ampicillin is released, followed by a slower release rate and then a final stage where the release amount approaches zero, until no more sodium ampicillin was present. X-ray photoeletron spectroscopy (XPS) studies were carried out in order to ensure that the entire antibiotic adsorbed onto the materials had been released. These kinetics studies have indicated the possibility of using these materials as possible carriers for drug delivery. Copyright © 2001 Elsevier Science Ltd. |
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