| Title | E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions |
| Publication Type | Journal Article |
| 2012 |
| Authors | Carneiro, P, Fernandes, MS, Figueiredo, J, Caldeira, J, Carvalho, J, Pinheiro, H, Leite, M, Melo, S, Oliveira, P, Simões-Correia, J, Oliveira, MJ, Carneiro, F, Figueiredo, C, Paredes, J, Oliveira, C, Seruca, R |
| Journal | FEBS LettersFEBS Lett. |
| Volume | 586 |
| Issue | 18 |
| Pagination | 2981 - 2989 |
| Date Published | 2012/// |
| 00145793 (ISSN) |
| Adhesion, Cadherins, cancer growth, cancer invasion, cancer patient, cancer susceptibility, cell adhesion, complex formation, conference paper, E-cadherin, embryo development, endocytosis, epigenetics, epithelial mesenchymal transition, Gastric cancer, gene mutation, gene silencing, genetic susceptibility, Germ-Line Mutation, HDGC, Helicobacter infection, Helicobacter Infections, Helicobacter pylori, histone deacetylase inhibitor, human, Humans, Invasion, metastasis, molecular pathology, nonhuman, priority journal, protein analysis, protein depletion, protein expression, protein function, protein structure, regulatory mechanism, signal transduction, Signalling, stomach cancer, stomach carcinogenesis, Stomach Neoplasms, Tumour, uvomorulin |
| E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922992&partnerID=40&md5=455ae054dc6c8f95dc9e81d77fec1ad9 |
