| Title | Granules of osteoapatite and glass-reinforced hydroxyapatite implanted in rabbit tibiae |
| Publication Type | Journal Article |
| 1996 |
| Authors | Afonso, A, Santos, JD, Vasconcelos, M, Branco, R, Cavalheiro, J |
| Journal | Journal of Materials Science: Materials in MedicineJ. MATER. SCI. MATER. MED. |
| Volume | 7 |
| Issue | 8 |
| Pagination | 507 - 510 |
| Date Published | 1996/// |
| 09574530 (ISSN) |
| animal experiment, animal tissue, article, Bone, Bone formation, bone growth, Calcium Compounds, calcium phosphate, Composite materials, Fiber reinforced materials, glass, Glass fibers, Glass reinforced hydroxyapatite, Granular materials, histology, hydroxyapatite, implant, Implants (surgical), Magnesium, Microstructure, Modified hydroxyapatite, nonhuman, Optical microscopy, ossification, Osteoapatite, Oxides, Phosphates, Physiological models, potassium, priority journal, rabbit, Rabbit tibiae, Sodium, tibia, X ray diffraction analysis |
| Granules of a modified hydroxyapatite, glass-reinforced hydroxyapatite composite and commercial hydroxyapatite were implanted in rabbit tibiae. Histological studies were carried out after 1 and 2 months implantation periods using light and fluorescence microscopy. A much higher percentage of bone contact was developed for both the glass-reinforced hydroxyapatite composite and the modified hydroxyapatite when compared to commercial hydroxyapatite (89-91% versus 66%) after 2 months implantation. The mechanism of bone formation and growth around implants is discussed in terms of the influence of elements incorporated into these novel materials which are commonly found in bone tissues, such as Na, K and Mg, and the presence of a soluble β-tricalcium phosphate phase in the microstructure of the composite. |
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